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丁二酸单甲酯

丁二酸单甲酯用途

【用途一】
用于有机合成

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丁二酸单甲酯名称

[ CAS 号 ]:
3878-55-5

[ 中文名 ]:
丁二酸单甲酯

[ 英文名 ]:
4-Methoxy-4-oxobutanoic acid

[中文别名 ]:

[英文别名 ]:

4-Methoxy-4-oxobutanoic acid
mono-Methyl succinate
Butanedioic acid, monomethyl ester
mono-Methyl hydrogen succinate
MFCD00002788
EINECS 223-408-2

丁二酸单甲酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
259.2±0.0 °C at 760 mmHg

[ 熔点 ]:
54-57 °C(lit.)

[ 分子式 ]:
C₅H₈O₄

[ 分子量 ]:
132.115

[ 闪点 ]:
104.5±16.1 °C

[ 精确质量 ]:
132.042252

[ PSA ]:
63.60000

[ LogP ]:
-0.21

[ 外观性状 ]:
白色至灰白色晶体或结晶大块

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.436

[ 储存条件 ]:
2~8°C

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Combustible.

丁二酸单甲酯MSDS

详细MSDS(安全技术说明书)

丁二酸单甲酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2917190090

丁二酸单甲酯上下游产品

丁二酸单甲酯上游产品

丁二酸单甲酯下游产品

丁二酸单甲酯制备

1.将400g丁二酸酐和194ml甲醇一起加热回流1h，减压蒸除多余的甲醇，剩余物冷却结晶，真空干燥，得丁二酸一甲酯502-507g，收率95-96%。

2.制法：

于装有搅拌器、回流冷凝器的反应瓶中，加入丁二酸酐（2）400g（4.0mol），无水甲醇200mL，搅拌下加热回流35min左右，反应体系成为均相，而后再回流反应30min。减压蒸出甲醇，趁热将反应物倒入大的培养皿中，冷却后固化为固体。真空干燥至恒重，得化合物（1）502～507g，收率95%，mp57～58℃。

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丁二酸单甲酯海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

丁二酸单甲酯文献

Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 300(3) , R756-62, (2011)

Recent evidence suggests that an acute increase in the generation of phagocyte-like NADPH-oxidase (Nox)-mediated reactive oxygen species (ROS) may be necessary for glucose-stimulated insulin secretion...

Stimulation of insulin release in vivo by the methyl esters of succinic acid and glutamic acid.

Adv. Exp. Med. Biol. 426 , 231-4, (1997)

Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.

Am. J. Physiol. Endocrinol. Metab. 283(2) , E302-10, (2002)

Succinic acid methyl esters are potent insulin secretagogues in rat pancreatic islets, but they do not stimulate insulin release in mouse islets. Unlike rat and human islets, mouse islets lack malic e...

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