2-丁烯醛

2-丁烯醛用途

【用途一】
用作色谱分析标准物质、橡胶促进剂、抗氧剂及杀虫剂，也用于有机合成
【用途二】
用于制正丁醛、正丁醇、橡胶硫化促进剂、酒精变性剂和鞣剂等
【用途三】
有机合成原料，用于制取丁醛、丁醇、2-乙基己醇、山梨酸、3-甲氧基丁醛、3-甲氧基丁醇、丁烯酸、喹哪啶、顺丁烯二酸酐及吡啶系产品。另外，丁烯醛与丁二烯反应可制得环氧树脂原料及环氧增塑剂。与季戊成四醇反应可得到耐热树脂原料。丁烯醛还可用于制取选矿用发泡剂、染料及橡胶抗氧剂、杀虫剂及军用化学品。工业级丁烯醛实际上是反式异构体和顺式异构体组成的混合物[4170-30-3]。但顺式异构体不稳定，含量不到1%。
【用途四】
有机合成原料，用于制取丁醛；丁醇；2-乙基己醇；山梨酸；3-甲氧基丁醛；3-甲氧基丁醇；丁烯酸；喹哪啶；顺丁烯二酸酐及吡啶系产品巴豆醛有顺式和反式两种异构体。顺式异构体不稳定。普通商品是反式异构体。在水中的溶解度（重量%）：20℃为15.5℃；5℃为16.1。与水的共沸点为84℃，含丁烯醛75.7%（重量），纯丁烯醛易树脂化，能慢慢氧化成丁烯酸。

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2-丁烯醛名称

[ CAS 号 ]:
123-73-9

[ 中文名 ]:
巴豆醛

[ 英文名 ]:
Crotonaldehyde

[中文别名 ]:

[英文别名 ]:

2-BUTENAL
Topanel
CH3CH=CHCHO
Crotonal
2-BUTEN-1-AL
Bu-2-tenal
Topanel CA
t-2-Butenal
MFCD00007003
(E)-2-Butenal

2-丁烯醛物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
104.0±0.0 °C at 760 mmHg

[ 熔点 ]:
−76 °C(lit.)

[ 分子式 ]:
C₄H₆O

[ 分子量 ]:
70.090

[ 闪点 ]:
4.6±4.3 °C

[ 精确质量 ]:
70.041862

[ PSA ]:
17.07000

[ LogP ]:
0.51

[ 外观性状 ]:
水白色液体,辛辣并令人窒息的气味

[ 蒸汽密度 ]:
2.41 (vs air)

[ 蒸汽压 ]:
31.4±0.1 mmHg at 25°C

[ 折射率 ]:
1.402

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
150 g/L (20 ºC)

2-丁烯醛MSDS

详细MSDS(安全技术说明书)

2-丁烯醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GP9625000

CHEMICAL NAME :: Crotonaldehyde, (E)-

CAS REGISTRY NUMBER :: 123-73-9

LAST UPDATED :: 199707

DATA ITEMS CITED :: 30

MOLECULAR FORMULA :: C4-H6-O

MOLECULAR WEIGHT :: 70.10

WISWESSER LINE NOTATION :: VH1U2 -T

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 12 mg/m3/10M

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4000 mg/m3/30M

TOXIC EFFECTS :: Behavioral - excitement Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1510 mg/m3/2H

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - excitement Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 568 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1331 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 283,131,1992 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Gen Indu):8H TWA 2 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 ppm (6 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-DENMARK:TWA 2 ppm (6 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 2 ppm (6 mg/m3) JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (6 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (6 mg/m3);STEL 6 ppm (18 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CROTONALDEHYDE-air:10H TWA 2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

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2-丁烯醛安全信息

[ 符号 ]:

GHS02, GHS05, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311-H315-H318-H330-H335-H341-H373-H400

[ 警示性声明 ]:
P201-P210-P260-P280-P304 + P340 + P310-P370 + P378

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable;T+:Verytoxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R11;R24/25;R26;R37/38;R41;R48/22;R50;R68

[ 安全声明 (欧洲) ]:
S26-S28-S36/37/39-S45-S61-S28A

[ 危险品运输编码 ]:
UN 1143 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
GP9625000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1

2-丁烯醛合成路线

详细合成路线

2-丁烯醛上下游产品

2-丁烯醛上游产品

2-丁烯醛下游产品

2-丁烯醛制备

由乙醛在碱或阴离子交换树脂催化作用下液相缩合生成丁醇醛，丁醇醛再在稀酸中加热缩合脱水制得。每吨巴豆醛消耗乙醛1405kg；氢氧化钠4.7kg；醛酸4kg。

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2-丁烯醛文献

Methyl vinyl ketone, a toxic ingredient in cigarette smoke extract, modifies glutathione in mouse melanoma cells.

Chem. Pharm. Bull. 62(8) , 772-8, (2014)

Cigarette smoke contains many harmful chemicals, which contribute to the pathogenesis of smoking-related diseases such as chronic obstructive pulmonary disease, cancer and cardiovascular disease. The ...

Purity Determination of Acetaldehyde in an Acetaldehyde Certified Reference Material.

Anal. Sci. 31 , 463-8, (2015)

Acetaldehyde is regulated as a toxic substance in various fields, and the method for monitoring or analysis of acetaldehyde is important. However, handling is difficult because of the high reactivity ...

Cigarette smoke has sensory effects through nicotinic and TRPA1 but not TRPV1 receptors on the isolated mouse trachea and larynx.

Am. J. Physiol. Lung Cell. Mol. Physiol. 309 , L812-20, (2015)

Cigarette smoke (CS) exposes chemosensory nerves in the airways to a multitude of chemicals, some acting through the irritant receptors TRPV1 and TRPA1 but potentially also through nicotinic acetylcho...

更多文献

2-丁烯醛

2-丁烯醛用途

2-丁烯醛名称

2-丁烯醛物理化学性质

2-丁烯醛MSDS

详细MSDS(安全技术说明书)

2-丁烯醛毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

2-丁烯醛安全信息

2-丁烯醛合成路线

详细合成路线

2-丁烯醛上下游产品

2-丁烯醛上游产品

2-丁烯醛下游产品

2-丁烯醛制备

2-丁烯醛文献

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