依普菌素

依普菌素用途

依普菌素(Eprinomectin; MK-397)是一种阿维菌素,具有驱虫,杀虫杀螨活性。

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依普菌素作用

乙酰氨基阿维菌素对线虫及节肢动物有驱杀作用，能增加虫体的抑制性递质γ-氨基丁酸（GABA）的释放，以及打开谷氨酸控制的Cl-通道，增强神经膜对Cl-的通透性，从而阻断神经信号的产地，最终神经麻痹，是肌肉细胞失去收缩能力，而导致虫体死亡。哺乳动物外周神经递质为乙酰胆碱，GABA虽分布于中枢神经系统，但由于本类药物不易通过血脑屏障，而对其影响极小，因此使用时就比较安全。本类药物影响寄生虫生殖的机理还不清楚，但能使蜱减少产卵，反刍兽线虫虫卵形态异常和使丝状线虫不育。其在牛奶中最大药物浓度远低于血浆中药物浓度，在奶中的分配量很低。

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依普菌素名称

[ CAS 号 ]:
123997-26-2

[ 中文名 ]:
依普菌素

[ 英文名 ]:
Eprinomectin

[中文别名 ]:

[英文别名 ]:

(4''R)-4''-(Acetylamino)-4''-deoxyavermectin B1
Eprinomectin
Eprinex
EINECS 200-835-2
MFCD07370747

依普菌素生物活性

[ 描述 ]:

依普菌素(Eprinomectin; MK-397)是一种阿维菌素,具有驱虫,杀虫杀螨活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Baoliang P, et al. Pharmacokinetics of eprinomectin in plasma and milk following subcutaneous administration to lactating dairy cattle. Vet Res Commun. 2006 Apr;30(3):263-70.

[2]. Visser M, et al. The treatment of bovine sarcoptic mange (Sarcoptes scabiei var. bovis) using eprinomectin extended-release injection. Vet Parasitol. 2013 Mar 1;192(4):359-64.

[3]. Shoop WL, et al. Eprinomectin: a novel avermectin for use as a topical endectocide for cattle. Int J Parasitol. 1996 Nov;26(11):1237-42.

[相关活性小分子]

依普菌素物理化学性质

[ 密度 ]:
1.23

[ 熔点 ]:
163-166 ºC

[ 分子式 ]:
C₅₀H₇₅NO₁₄

[ 分子量 ]:
914.13

[ 闪点 ]:
2 °C

[ PSA ]:
178.93000

[ LogP ]:
5.46970

[ 外观性状 ]:
灰白色或米色粉末

[ 储存条件 ]:
2-8°C

依普菌素安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H361-H400

[ 警示性声明 ]:
P273-P281-P301 + P310

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
F,Xn,N,T

[ 风险声明 (欧洲) ]:
11-20/21/22-36-62-50/53-25-63

[ 安全声明 (欧洲) ]:
26-36/37-16-61-60-45

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

依普菌素文献

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel, against the ticks, Ixodes ricinus and Ixodes scapularis, on cats.

Vet. Parasitol. 202(1-2) , 59-63, (2014)

Five controlled, blinded and randomized studies were conducted to examine the efficacy of a single topical application of a combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BRO...

Efficacy of a single dose of a novel topical combination product containing eprinomectin to prevent heartworm infection in cats

Vet. Parasitol. 202(1-2) , 49-53, (2014)

Cats may be infected by heartworm, Dirofilaria immitis, through mosquito bites. They can develop severe heartworm disease when infective D. immitis larvae migrate and develop into adults in the pulmon...

Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against experimental infections ofToxascaris leoninain cats

Vet. Parasitol. 202(1-2) , 40-4, (2014)

The efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product (BROADLINE®, Merial) was evaluated against adult Toxascaris leonina ascarids in experimental...

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