< 生产厂家价格 >

N,N'-六亚甲基双乙酰胺

N,N'-六亚甲基双乙酰胺用途

六亚甲基二乙酰胺是一种肿瘤细胞分化剂[1]。

点击显示

N,N'-六亚甲基双乙酰胺名称

[ CAS 号 ]:
3073-59-4

[ 中文名 ]:
N,N′-六亚甲基双乙酰胺

[ 英文名 ]:
Hexamethylene bisacetamide

[中文别名 ]:

[英文别名 ]:

N,N‘-Hexamethylenebisacetamide
N,N'-hexamethylene bis(acetamide)
Hexamethylenediacetamide
N,N'-diacetyl-1,6-hexanediamine
hmba
N,N′-Diacetyl-1,6-diaminohexane
diacetyldiaminohexane
EINECS 211-363-1
hexamethylenebis(acetamide)
N,N-Hexamethylenediacetamide

N,N'-六亚甲基双乙酰胺生物活性

[ 描述 ]:

六亚甲基二乙酰胺是一种肿瘤细胞分化剂[1]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Reuben RC, et al. A new group of potent inducers of differentiation in murine erythroleukemia cells. Proc Natl Acad Sci U S A. 1976 Mar;73(3):862-6.

N,N'-六亚甲基双乙酰胺物理化学性质

[ 密度 ]:
0.974 g/cm3

[ 沸点 ]:
456.7ºC at 760 mmHg

[ 熔点 ]:
128-129 °C(lit.)

[ 分子式 ]:
C₁₀H₂₀N₂O₂

[ 分子量 ]:
200.28

[ 闪点 ]:
193.2ºC

[ 精确质量 ]:
200.15200

[ PSA ]:
58.20000

[ LogP ]:
1.60080

[ 外观性状 ]:
白色片状

[ 储存条件 ]:
室温，干燥

N,N'-六亚甲基双乙酰胺MSDS

详细MSDS(安全技术说明书)

N,N'-六亚甲基双乙酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC2976200

CHEMICAL NAME :: Acetamide, N,N'-hexamethylenebis-

CAS REGISTRY NUMBER :: 3073-59-4

BEILSTEIN REFERENCE NO. :: 1775764

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H20-N2-O2

MOLECULAR WEIGHT :: 200.32

WISWESSER LINE NOTATION :: 1VM6MV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4270 mg/kg/10D-C

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - thrombocytopenia

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,5788,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3250 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985

点击显示

N,N'-六亚甲基双乙酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R33:Danger of cumulative effects.

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AC2976200

[ 海关编码 ]:
2924199090

N,N'-六亚甲基双乙酰胺上下游产品

N,N'-六亚甲基双乙酰胺上游产品

N,N'-六亚甲基双乙酰胺下游产品

N,N'-六亚甲基双乙酰胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N,N'-六亚甲基双乙酰胺文献

Balancing polymer hydrophobicity for ligand presentation and siRNA delivery in dual function CXCR4 inhibiting polyplexes.

Biomater. Sci. 3 , 1114-23, (2015)

In the present study, a series of copolymers (PAMD-Ch) was synthesized by grafting polymeric Plerixafor/AMD3100 (PAMD) with different amounts of cholesterol and the effect of cholesterol modification ...

Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.

Exp. Hematol. 43 , 393-403.e2, (2015)

Thioredoxin-interacting protein (TXNIP) is involved in various cellular processes including redox control, metabolism, differentiation, growth, and apoptosis. With respect to hematopoiesis, TXNIP has ...

Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.

J. Virol. 89 , 9841-52, (2015)

It has recently been proposed that the herpes simplex virus (HSV) protein ICP0 has cytoplasmic roles in blocking antiviral signaling and in promoting viral replication in addition to its well-known pr...

更多文献