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(±)-樟脑(合成)

(±)-樟脑(合成)用途

Camphor ((±)-Camphor) 是一种外用抗感染和抗瘙痒剂,口服有驱风作用。然而,Camphor 摄入时有毒。Camphor 具有抗病毒,镇咳和抗癌活性[1]。Camphor 是一种 TRPV3 激动剂[2]。
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(±)-樟脑(合成)名称

[ CAS 号 ]:
76-22-2

[ 中文名 ]:
樟脑

[ 英文名 ]:
(+/-)-Camphor

[中文别名 ]:

[英文别名 ]:

(±)-樟脑(合成)生物活性

[ 描述 ]:

Camphor ((±)-Camphor) 是一种外用抗感染和抗瘙痒剂,口服有驱风作用。然而,Camphor 摄入时有毒。Camphor 具有抗病毒,镇咳和抗癌活性[1]。Camphor 是一种 TRPV3 激动剂[2]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道
天然产物 >> 萜类化合物和糖苷
研究领域 >> 癌症
研究领域 >> 炎症/免疫
研究领域 >> 感染

[ 靶点 ]

TRPV3[2]


[体外研究]

樟脑通过PI3K/AKT和ERK信号传导途径诱导成纤维细胞增殖。 MTT测定结果显示,与0μMCamphor处理相比,32.5,65,130和260μM樟脑的成纤维细胞活力分别增加至108.9±6.6％,118.6±2.8％,127.7±4.2％和131.6±7.2％。樟脑处理24小时后,ROS的产生量增加了17.97％,而未处理对照组为5.04％[3]。

[细胞实验]

将原代真皮成纤维细胞（2×10 4个细胞/ mL）细胞接种在96孔板中的200μL含有10％FBS的培养基中。 24小时后，用各种浓度的洋甘菊水溶胶或樟脑（0-260μM）处理细胞。处理后，向每个孔中加入20μLMTT溶液（5mg / mL），然后在潮湿环境中孵育3-4小时。除去上清液并加入150μLDMSO。细胞活力由570nm处的吸光度确定，使用Sunrise酶标仪测量[3]。

[参考文献]

[1]. Chen W, et al. Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. Molecules. 2013 May 10;18(5):5434-54.

[2]. Billen B, et al. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealedby intrinsic tryptophan fluorescence quenching. J Biol Chem. 2015 May 15;290(20):12964-74.

[3]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25.


[相关活性小分子]

辣椒碱 | 辣椒平 | 5-(N-乙基-N-异丙基)阿米洛利 | 氯化二亚苯基碘鎓 | 2-(1,3-二甲基-2,6-二氧代-2,3-二氢-1H-嘌呤-7(6H)-基)-N-(4-异丙基苯基)乙酰胺 | 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑 | HC-067047 | AMG9810 | GSK1016790A | SAR7334 | PF-4840154 | RN-1734 | AMG 517 | 3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺 | 冰素

(±)-樟脑(合成)物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
207.4±0.0 °C at 760 mmHg

[ 熔点 ]:
175-177 °C(lit.)

[ 分子式 ]:
C10H16O

[ 分子量 ]:
152.233

[ 闪点 ]:
64.4±0.0 °C

[ 精确质量 ]:
152.120117

[ PSA ]:
17.07000

[ LogP ]:
2.13

[ 外观性状 ]:
无色或白色的结晶粉末,带有一种强烈的像樟脑丸的气味

[ 蒸汽密度 ]:
5.2 (vs air)

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.485

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics.

[ 水溶解性 ]:
0.12 g/100 mL (25 ºC)

(±)-樟脑(合成)MSDS

详细MSDS(安全技术说明书)

(±)-樟脑(合成)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EX1225000
CHEMICAL NAME :
Camphor
CAS REGISTRY NUMBER :
76-22-2
BEILSTEIN REFERENCE NO. :
3196099
LAST UPDATED :
199712
DATA ITEMS CITED :
50
MOLECULAR FORMULA :
C10-H16-O
MOLECULAR WEIGHT :
152.26
WISWESSER LINE NOTATION :
L55 A CVTJ A1 A1 B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
51 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
29 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/m3/3H
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
210 mg/m3/3H/7W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - emphysema
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
33 mg/m3/3H/7W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Cardiac - other changes Lungs, Thorax, or Respiration - emphysema

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,157,1989 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 19 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 12 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB293-503 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 2 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,37,1971 OSHA PEL (Gen Indu):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (19 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.3 ppm (2 mg/m3);STEL 0.9 ppm (6 mg/m3) JAN 1993 OEL-FRANCE:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-GERMANY:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CAMPHOR, synthetic-air:10H TWA 2 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 15800 No. of Facilities: 8356 (estimated) No. of Industries: 68 No. of Occupations: 63 No. of Employees: 95578 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1190 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 427 (estimated) No. of Female Employees: 176 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 15800 No. of Facilities: 9166 (estimated) No. of Industries: 101 No. of Occupations: 87 No. of Employees: 153554 (estimated) No. of Female Employees: 53187 (estimated)
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(±)-樟脑(合成)安全信息

[ 符号 ]:

GHS02, GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H228-H302 + H332-H371

[ 警示性声明 ]:
P210-P260-P301 + P312 + P330-P370 + P378

[ 靶器官 ]:
Lungs

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R36/37/38

[ 安全声明 (欧洲) ]:
S16-S26-S37/39

[ 危险品运输编码 ]:
UN 2717 4.1/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
EX1225000

[ 包装等级 ]:
III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
2914291000

(±)-樟脑(合成)合成路线

详细合成路线

(±)-樟脑(合成)上下游产品

(±)-樟脑(合成)上游产品

(±)-樟脑(合成)下游产品

(±)-樟脑(合成)制备

1.以樟树的叶、枝桠、木片为原料，采用水蒸气蒸馏法提取樟脑。

将原料装于木甑中，汽化锅内加水，进行水上蒸馏，导出的油水蒸气经冷凝得到樟脑结晶。结晶樟脑经离心机分离送至蒸馏釜加热熔化后，进行精馏，冷却结晶回收樟脑。此时樟脑纯度高达96%以上。然后通过升华锅升华精制即得成品。

精制方法：有升华法、蒸馏法、分步结晶法和溶剂结晶法等。用溶剂结晶法精制时常用的溶剂有50%的乙醇水溶液和溶剂汽油。此外，也可以将樟脑溶解于浓乙酸后加水沉淀的方法进行精制。

2.天然樟脑的制备　樟树是我国的特产树种，其根、茎、枝、叶都含有樟脑和樟油。

3.合成樟脑的制备莰烯的制备　以松节油为原料，提取其中的蒎烯，经异构化得含莰烯的异构液。莰烯分馏　含莰烯的异构液由贮槽泵至高位槽，经转子流量计计量和预热器预热后，连续进入莰烯蒸馏塔，进行减压蒸馏，得到含莰烯91%以上的工业莰烯。莰烯直接水合生成异龙脑　用泵把水槽的无离子水打入配料槽，把莰烯从贮槽放入异丙醇贮槽溶解，用泵打到配料槽与无离子水混合均匀后，用泵打到高位槽然后连续流经预热器，再进入水合反应柱进行反应。含异龙脑的反应液放入贮槽，经泵泵至高位槽，然后连续进入连蒸器，馏出物经冷凝器冷凝成液体回流入配料槽重新用作配料，器底的粗异龙脑液连续出料入贮槽，经泵把粗异龙脑液泵入带搅拌装置和夹套的浓缩锅进一步加热浓缩，馏出物经冷凝器冷凝成液体回流入配料槽重新用作配料，当温度达到100℃时停止夹套加热，改为夹套通冷却水冷却。异龙脑浓缩液经搅拌结晶后，放入贮槽，经离心机进行水洗、甩干，得到异龙脑装桶。其中，一部分作为产品销售，大部分用于生产药用樟脑。离心分离的油状物和洗涤水并入副产油回收工段。异龙脑脱氢生成樟脑　在脱氢锅内加入异龙脑，加入一定量的二甲苯溶解之，把碱式碳酸铜催化剂按加入量分几次加入脱氢锅，在180～200℃下进行脱氢反应，氢气经鼓泡器和阻火器排至大气。脱氢至终点后生成樟脑。樟脑纯化成药用樟脑　在脱氢锅内加入后处理新催化剂进行后处理。然后把樟脑放入汽化锅汽化，连续进入樟脑分馏塔进行常压分馏。馏出物送到二甲苯回收塔分馏回收二甲苯和莰烯复用。塔底熔融的樟脑连续进入升华锅，并用油浴升温至210℃，樟脑不断升华，入升华室冷却成为药用樟脑，不凝性气体经过水喷淋装置回收樟脑后排入大气。
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(±)-樟脑(合成)海关

[ 海关编码 ]: 2914291000

(±)-樟脑(合成)文献

Carvacrol and rosemary essential oil manifest cytotoxic, DNA-protective and pro-apoptotic effect having no effect on DNA repair.

Neoplasma 61(6) , 690-9, (2014)

For several thousand years natural products were successfully used to treat a variety of diseases and to maintain health in humans, but until now it is not fully known what causes these medicinal effe...

In vitro antifungal activity and probable fungicidal mechanism of aqueous extract of Barleria grandiflora.

Appl. Biochem. Biotechnol. 175(8) , 3571-84, (2015)

Barleria grandiflora Dalz. (Acanthaceae) is being used in India to treat different types of disorders including skin infections. Therefore, there are good possibilities to find antifungal compounds in...

Development and application of a non-targeted extraction method for the analysis of migrating compounds from plastic baby bottles by GC-MS.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 31(12) , 2090-102, (2014)

In 2011, the European Union prohibited the production of polycarbonate (PC) baby bottles due to the toxic effects of the PC monomer bisphenol-A. Therefore, baby bottles made of alternative materials, ...


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相关化工产品/化学物质：

推荐生产厂家/供应商：

公司名：南通润丰石油化工有限公司

区域：南通市崇川区

价格：
￥需询单/1kg ￥需询单/1ton

联系人：曹经理

产品详情：合成樟脑

公司名：云南西力生物技术股份有限公司

区域：昆明市盘龙区

价格：
￥需询单/50mg

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公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥88.0/100mg

联系人：刘佳

产品详情：樟脑

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区域：上海市嘉定区

价格：
￥489.0/100mg ￥需询单/1g ￥需询单/1g ￥需询单/1g

联系人：李先生

产品详情：Camphor

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥58.0/100g ￥193.0/500g ￥702.0/2500g ￥490.0/100mg

联系人：夏言

产品详情：[Perfemiker](±)-樟脑(合成),96%

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相关化合物

【(±)-樟脑(合成)】化源网提供(±)-樟脑(合成)CAS号76-22-2，(±)-樟脑(合成)MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询(±)-樟脑(合成)上化源网，专业又轻松。>>电脑版：(±)-樟脑(合成)

标题：(±)-樟脑(合成)_MSDS_用途_密度_CAS号【76-22-2】_化源网 地址：https://m.chemsrc.com/mip/cas/76-22-2_895629.html