< 生产厂家价格 >

Ro 41-0960

Ro 41-0960用途

Ro 41-0960是一种选择性儿茶酚-O-甲基转移酶(COMT)抑制剂[1]。

点击显示

Ro 41-0960名称

[ CAS 号 ]:
125628-97-9

[ 英文名 ]:
Ro 41-0960

[英文别名 ]:

OR 1139
3,4-dihydroxy-5-nitrophenyl 2-fluorophenyl ketone
2'-fluoro-3,4-dihydroxy-5-nitrobenzophenone
3,4-dihydroxy-5-nitro-2'-fluorobenzophenone
Ro 41-0960
2'-Fluoro-3,4-dihydroxy-5-nitrobenzophenone

Ro 41-0960生物活性

[ 描述 ]:

Ro 41-0960是一种选择性儿茶酚-O-甲基转移酶(COMT)抑制剂[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> COMT

研究领域 >> 神经疾病

信号通路 >> 代谢酶/蛋白酶 >> COMT

[参考文献]

[1]. Storch A, et al. Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons. Mol Pharmacol. 2000 Mar;57(3):589-94.

Ro 41-0960物理化学性质

[ 密度 ]:
1.536g/cm3

[ 沸点 ]:
489.9ºC at 760 mmHg

[ 分子式 ]:
C₁₃H₈FNO₅

[ 分子量 ]:
277.20500

[ 闪点 ]:
250.1ºC

[ 精确质量 ]:
277.03900

[ PSA ]:
103.35000

[ LogP ]:
2.89930

[ 蒸汽压 ]:
3.2E-10mmHg at 25°C

[ 折射率 ]:
1.656

Ro 41-0960MSDS

详细MSDS(安全技术说明书)

Ro 41-0960毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PC4952300

CHEMICAL NAME :: Methanone, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-

CAS REGISTRY NUMBER :: 125628-97-9

LAST UPDATED :: 199509

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H8-F-N-O5

MOLECULAR WEIGHT :: 277.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 312 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 72,952,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 136 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 69,64,1991

点击显示

Ro 41-0960安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
PC4952300

Ro 41-0960文献

Organic cation transporter 3 contributes to norepinephrine uptake into perivascular adipose tissue.

Am. J. Physiol. Heart Circ. Physiol. 309 , H1904-14, (2015)

Perivascular adipose tissue (PVAT) reduces vasoconstriction to norepinephrine (NE). A mechanism by which PVAT could function to reduce vascular contraction is by decreasing the amount of NE to which t...

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

J. Biol. Chem. 290 , 13992-4003, (2015)

Neurotransmitter:sodium symporters (NSSs) terminate neurotransmission by Na(+)-dependent reuptake of released neurotransmitters. Previous studies suggested that Na(+)-binding reconfigures dynamically ...

Elevated expression of catechol-O-methyltransferase is associated with labor and increased prostaglandin E2production by human fetal membranes

Am. J. Obstet. Gynecol. 201(5) , 496.e1-7, (2009)

Objective The purpose of this study was to evaluate the expression and function of catechol-O-methyltransferase in human fetal membranes at term.

更多文献