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α-D-Gal-(1→4)-β-D-Gal-(1→4)-β-D-Glc-1→O-sphingosine

用途

Globotriaosylsphingosine (lyso-Gb3) 抑制成纤维细胞的生长,以及它们向肌成纤维细胞的分化和胶原蛋白的表达。Globotriaosylsphingosine 可用于法布里病的研究。

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名称

[ CAS 号 ]:
126550-86-5

[ 中文名 ]:
α-D-Gal-(1→4)-β-D-Gal-(1→4)-β-D-Glc-1→O-sphingosine

[ 英文名 ]:
Lyso-Globotriaosylceramide (d18:1)

[英文别名 ]:

生物活性

[ 描述 ]:

Globotriaosylsphingosine (lyso-Gb3) 抑制成纤维细胞的生长,以及它们向肌成纤维细胞的分化和胶原蛋白的表达。Globotriaosylsphingosine 可用于法布里病的研究。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钙通道

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Choi JY, et al. Lyso-globotriaosylceramide downregulates KCa3.1 channel expression to inhibit collagen synthesis in fibroblasts. Biochem Biophys Res Commun. 2015 Dec 25;468(4):883-8.

[2]. Auray-Blais C, et al. How well does urinary lyso-Gb3 function as a biomarker in Fabry disease? Clin Chim Acta. 2010 Dec 14;411(23-24):1906-14.

物理化学性质

[ 密度 ]:
1.37g/cm3

[ 沸点 ]:
1005.8ºC at 760 mmHg

[ 分子式 ]:
C₃₆H₆₇NO₁₇

[ 分子量 ]:
785.91400

[ 闪点 ]:
562.1ºC

[ 精确质量 ]:
785.44100

[ PSA ]:
303.93000

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.591

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

LC–MS/MS analysis of plasma lyso-Gb3 in Fabry disease

Clin. Chim. Acta 414 , 273-80, (2012)

Background Fabry disease is a complex, multisystemic and clinically heterogeneous disease, with elevated excretion of globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) accumulating i...

A metabolomic study reveals novel plasma lyso-Gb3 analogs as Fabry disease biomarkers.

Curr. Med. Chem. 20(2) , 280-8, (2013)

Fabry disease is an X-linked, multisystemic lysosomal storage disorder due to alpha-galactosidase A deficiency. It is characterized by the accumulation of glycosphingolipids, mainly globotriaosylceram...

In vivo tumor targeting using a novel intestinal pathogen-based delivery approach.

Cancer Res. 66(14) , 7230-6, (2006)

Efficient methods for tumor targeting are eagerly awaited and must satisfy several challenges: molecular specificity, transport through physiologic barriers, and capacity to withstand extracellular or...

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