< 生产厂家价格 >

熊去氧胆酸

熊去氧胆酸用途

Ursodiol能降低胆固醇吸收,可作用于胆结石的溶解。

点击显示

熊去氧胆酸名称

[ CAS 号 ]:
128-13-2

[ 中文名 ]:
熊去氧胆酸

[ 英文名 ]:
Ursodiol

[中文别名 ]:

[英文别名 ]:

(3a,5b,7b,8x)-3,7-dihydroxycholan-24-oic acid
Ursofalk
3α,7β-Dihydroxy-6β-cholan-24-oic acid
Ursolvan
Ursochol
Peptarom
Actigall
Delursan
Ursodeoxycholic acid
(3α,5β,7β)-3,7-Dihydroxycholan-24-oic acid

熊去氧胆酸生物活性

[ 描述 ]:

Ursodiol能降低胆固醇吸收,可作用于胆结石的溶解。

[ 相关类别 ]:

天然产物 >> 类固醇

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Jackson H, et al. Influence of ursodeoxycholic acid on the mortality and malignancy associated with primary biliary cirrhosis: a population-based cohort study. Hepatology. 2007 Oct;46(4):1131-7.

[2]. Kumar D, et al. Use of ursodeoxycholic acid in liver diseases. J Gastroenterol Hepatol. 2001 Jan;16(1):3-14.

[相关活性小分子]

熊去氧胆酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
547.1±25.0 °C at 760 mmHg

[ 熔点 ]:
203-206 ºC

[ 分子式 ]:
C₂₄H₄₀O₄

[ 分子量 ]:
392.572

[ 闪点 ]:
298.8±19.7 °C

[ 精确质量 ]:
392.292664

[ PSA ]:
77.76000

[ LogP ]:
4.66

[ 外观性状 ]:
固体;White to Almost white powder to crystaline

[ 蒸汽压 ]:
0.0±3.3 mmHg at 25°C

[ 折射率 ]:
1.543

[ 储存条件 ]:
2~8°C

[ 水溶解性 ]:
不溶

熊去氧胆酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
FZ2000000

熊去氧胆酸合成路线

详细合成路线

熊去氧胆酸制备

点击显示

熊去氧胆酸文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

[Preventive administration of new UDCA derivatives in experimental alcoholic steatohepatitis].

Eksp. Klin. Farmakol. 76(1) , 25-9, (2013)

We have studied the prophylactic effect of new derivatives of ursodeoxycholic acid (UDCA), including UDCA-N-acetylcysteine, UDCA-L-acetylcysteine, and nor-UDCA (in doses equivalent to 40 mg/kg of UDCA...

更多文献