双氢链霉素
双氢链霉素用途
属抗生素类药,主要用于固紫染色阴性杆菌感染,也可用于结核杆菌感染。
双氢链霉素名称
[ CAS 号 ]:
128-46-1
[ 中文名 ]:
双氢霉素
[ 英文名 ]:
Dihydrostreptomycin
[中文别名 ]:
[英文别名 ]:
- Dihydrostreptomycin
- Abiocine
- Dihydrostreptomycine
- Panstreptin
- DST
- dhms
- Acetonitrile,2-benzimidazolyl
- dihydro-streptomyci
- Vibriomycin
- MFCD00084778
双氢链霉素物理化学性质
[ 密度 ]:
2.0±0.1 g/cm3
[ 沸点 ]:
879.5±75.0 °C at 760 mmHg
[ 熔点 ]:
210 - 212ºC
[ 分子式 ]:
C21H41N7O12
[ 分子量 ]:
583.590
[ 闪点 ]:
485.7±37.1 °C
[ 精确质量 ]:
583.281311
[ PSA ]:
334.59000
[ LogP ]:
-3.38
[ 外观性状 ]:
略米色固体
[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C
[ 折射率 ]:
1.762
双氢链霉素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WK2450000
- CHEMICAL NAME :
- Streptamine, O-beta-D-mannopyranosyl-(1-4)-2-deoxy-2-(methylamino) -alpha-L-glucopyranos yl- (1-2)-5-deoxy-O-3-C-(hydroxymethyl)-alpha-L-lyxofuran osyl-(1-4)-N,N'-diami dino-, D-
- CAS REGISTRY NUMBER :
- 128-46-1
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C21-H41-N7-O12
- MOLECULAR WEIGHT :
- 583.69
- WISWESSER LINE NOTATION :
- T6OTJ CM1 DQ EQ F1Q BO- CT5OTJ DQ D1Q E1 BO- AL6TJ BQ CQ DMYZUM EQ FMYZUM
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 533 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 260 mg/kg
- SEX/DURATION :
- female 19-22 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- female 1-16 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 6-10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 7500 mg/kg
- SEX/DURATION :
- female 5-19 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 12 gm/kg
- SEX/DURATION :
- female 1-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- REFERENCE :
- NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 14,161,1971
双氢链霉素合成路线
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