山茱萸新苷

山茱萸新苷用途

Cornuside 是一种从山茱萸 (Cornus officinalis Sieb. et Zucc.) 的果实中分离出的环烯醚萜苷,山茱萸是一种传统的东方医药,用于治疗炎症性疾病和促进血液循环。 Cornuside 通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应。Cornuside 的体内和体外抗过敏作用表明该药物在炎性过敏性疾病中的治疗应用。

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山茱萸新苷名称

[ CAS 号 ]:
131189-57-6

[ 中文名 ]:
山茱萸新苷

[ 英文名 ]:
Cornuside

[中文别名 ]:

山茱萸新苷I

[英文别名 ]:

Y0054
N1926
Cornuside

山茱萸新苷生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> MAPK/ERK信号通路 >> p38 MAPK

研究领域 >> 炎症/免疫

[ 靶点 ]

p38 MAP kinase

NF-κB

[参考文献]

[1]. Li L, et al. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Biochem Biophys Res Commun. 2016 Apr 29;473(2):408-14.

山茱萸新苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
817.6±65.0 °C at 760 mmHg

[ 分子式 ]:
C₂₄H₃₀O₁₄

[ 分子量 ]:
542.487

[ 闪点 ]:
274.5±27.8 °C

[ 精确质量 ]:
542.163574

[ PSA ]:
221.90000

[ LogP ]:
-0.31

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.648

[ 储存条件 ]:
-20℃，密封，干燥

山茱萸新苷MSDS

详细MSDS(安全技术说明书)

山茱萸新苷安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

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山茱萸新苷文献

[Optimization of microwave-assisted extraction with RSM and HPLC determination for three iridoid glycosides in Cornus officinalis].

Zhong Yao Cai 34(7) , 1118-22, (2011)

To establish a method of microwave-assisted extraction and high performance liquid chromatographic (HPLC) for simultaneous determination of three iridoid glycosides including loganin, sweroside and co...

Simultaneous determination of six active components in crude and processed Fructus Corni by high performance liquid chromatography.

J. Pharm. Biomed. Anal. 48(1) , 194-7, (2008)

A simple and rapid HPLC method was established for simultaneously determining six active components in Fructus Corni. The six components were separated on an Agilent Zorbax Extend C18 column (250 mmx4...

[Studies on the chemical constituents of Cornus officinalis Sieb et Zucc].

Yao Xue Xue Bao 27(11) , 845-8, (1992)

A new bisiridoid glucoside named cornuside was isolated from the fruits of Cornus officinalis Sieb et Zucc. The structure of cornuside has been established by spectroscopic methods (IR, MS, 1HNMR, 13C...

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