Tirofiban-d9

Tirofiban-d9用途

替罗非班-d9是氘标记的替罗非班。
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Tirofiban-d9名称

[ CAS 号 ]:
1332075-40-7

[ 英文名 ]:
Tirofiban-d9

Tirofiban-d9生物活性

[ 描述 ]:

替罗非班-d9是氘标记的替罗非班。

[ 相关类别 ]:

研究领域 >> 心血管疾病
信号通路 >> 细胞骨架 >> Integrin

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Winter JP, Juergens CP. The role of tirofiban in the management of coronary artery disease. Cardiovasc Hematol Disord Drug Targets. 2008 Jun;8(2):138-46.

[3]. van 't Hof AW, Valgimigli M. Defining the role of platelet glycoprotein receptor inhibitors in STEMI: focus on tirofiban. Drugs. 2009;69(1):85-100.

[4]. Valgimigli M, Biondi-Zoccai G, Tebaldi M et al. Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of randomized trials. Eur Heart J. 2010 Jan;31(1):35-49.

[5]. Valgimigli M, Tebaldi M. Safety evaluation of tirofiban. Expert Opin Drug Saf. 2010 Sep;9(5):801-19.

[6]. Diaz JF, Cardenal R, Gomez-Manchero A, Sanchez-Gonzalez C. Safety and efficacy of tirofiban as adjunctive therapy for patients with ST-elevation myocardial infarction: a comparison versus placebo and abciximab. Cardiovasc Hematol Agents Med Chem. 2011 Jul 1;9(3):147-53.

Tirofiban-d9物理化学性质

[ 分子式 ]:
C22H27D9N2O5S

[ 分子量 ]:
449.65

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相关化合物

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标题：【Tirofiban-d9】Tirofiban-d9 CAS号:1332075-40-7【结构式 性质 活性】-化源网 地址：https://m.chemsrc.com/mip/cas/1332075-40-7_1707097.html