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盐酸脱水四环素

盐酸脱水四环素用途

盐酸脱水四环素是四环素生物合成的前体,是一种有效的竞争性广谱四环素破坏酶抑制剂。盐酸脱水四环素是真核细胞中四环素控制基因表达系统的效应剂[1]。

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盐酸脱水四环素名称

[ CAS 号 ]:
13803-65-1

[ 中文名 ]:
乳糖

[ 英文名 ]:
Anhydrotetracycline Hydrochloride

[中文别名 ]:

脱水四环素盐酸盐

[英文别名 ]:

5A,6-ANHYDROTETRACYCLINEHYDROCHLORIDE
Anhydrotetracycline hydrochloride
AnhydrotetracyclineHCl
MFCD00151453

盐酸脱水四环素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体外研究]

盐酸脱水四环素对四环素类药物Tet(50)(IC50=210μM)、Tet(X)(IC50=41μM)、Tet(X)3(IC50=3μM)的降解有抑制作用。盐酸脱水四环素对金霉素Tet(50)(IC50=210μM)、Tet(X)(IC50=75μM)、Tet(X)Β3(IC50=26μM)的降解有抑制作用。盐酸脱水四环素抑制去甲氯环素的Tet(50)(IC50=120μM)、Tet(X)(IC50=41μM)、Tet(X)3(IC50=7μM)降解[1]。盐酸脱水四环素对四环素类药物Tet(50)(IC50=210μM)、Tet(X)(IC50=41μM)、Tet(X)3(IC50=3μM)的降解有抑制作用。盐酸脱水四环素对金霉素Tet(50)(IC50=210μM)、Tet(X)(IC50=75μM)、Tet(X)Β3(IC50=26μM)的降解有抑制作用。盐酸脱水四环素抑制去甲氯环素的Tet(50)(IC50=120μM)、Tet(X)(IC50=41μM)、Tet(X)3(IC50=7μM)降解[1]。

[参考文献]

[1]. Jana L Markley, et al. Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes. ACS Infect Dis. 2019 Apr 12;5(4):618-633.

盐酸脱水四环素物理化学性质

[ 沸点 ]:
618.6ºC at 760 mmHg

[ 熔点 ]:
222.8ºC

[ 分子式 ]:
C₂₂H₂₃ClN₂O₇

[ 分子量 ]:
462.880

[ 闪点 ]:
327.9ºC

[ 精确质量 ]:
462.119385

[ PSA ]:
161.39000

[ LogP ]:
1.95810

[ 外观性状 ]:
浅黄色至黄色至橙色至棕色粉末

[ 蒸汽压 ]:
3.66E-16mmHg at 25°C

[ 储存条件 ]:
室温

盐酸脱水四环素MSDS

详细MSDS(安全技术说明书)

盐酸脱水四环素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R63

[ 安全声明 (欧洲) ]:
S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
1702190000

盐酸脱水四环素合成路线

详细合成路线

盐酸脱水四环素上下游产品

盐酸脱水四环素上游产品

盐酸脱水四环素下游产品

盐酸脱水四环素海关

[ 海关编码 ]: 1702190000

盐酸脱水四环素文献

Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.

Bioorg. Med. Chem. Lett. 22 , 1709-11, (2012)

Over-expressions of miRNAs are being increasingly linked with many diseases including different types of cancer. In this study, the role of some known small molecular therapeutics has been investigate...

Tetracycline repressor allostery does not depend on divalent metal recognition.

Biochemistry 53(50) , 7990-8, (2014)

Genes that render bacteria resistant to tetracycline-derived antibiotics are tightly regulated by repressors of the TetR family. In their physiologically relevant, magnesium-complexed form, tetracycli...

Use of mCherry Red fluorescent protein for studies of protein localization and gene expression in Clostridium difficile.

Appl. Environ. Microbiol. 81(5) , 1652-60, (2015)

Fluorescent proteins are powerful reporters in biology, but most require O2 for chromophore maturation, making them inherently difficult to use in anaerobic bacteria. Clostridium difficile, a strict a...

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