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反式,反式-1,3-丁二烯-1,4-二羧酸

反式,反式-1,3-丁二烯-1,4-二羧酸用途

trans-trans-Muconic acid 是苯的一种泌尿代谢物,可被用作人体暴露于苯的生物标记。

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反式,反式-1,3-丁二烯-1,4-二羧酸名称

[ CAS 号 ]:
3588-17-8

[ 中文名 ]:
反式,反式-1,3-丁二烯-1,4-二羧酸

[ 英文名 ]:
trans,trans-Muconic Acid

[中文别名 ]:

[英文别名 ]:

(E,E)-muconic acid
muconic acid
2,4-HEXADIENEDIOIC ACID, (E,E)-
trans,trans muconic acid
MFCD00002702
Hexa-2t,4t-diendisaeure
EINECS 222-724-8
2,4-Hexadienedioic acid, (2E,4E)-
(E,E)-2,4-hexadienedioic acid
2,4-hexadienedioic acid

反式,反式-1,3-丁二烯-1,4-二羧酸生物活性

[ 描述 ]:

trans-trans-Muconic acid 是苯的一种泌尿代谢物,可被用作人体暴露于苯的生物标记。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Bartczak A, ET AL. Evaluation of assays for the identification and quantitation of muconic acid, a benzene metabolite in human urine. J Toxicol Environ Health. 1994 Jul;42(3):245-58.

[相关活性小分子]

反式,反式-1,3-丁二烯-1,4-二羧酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
345.4±15.0 °C at 760 mmHg

[ 熔点 ]:
290 °C (dec.)(lit.)

[ 分子式 ]:
C₆H₆O₄

[ 分子量 ]:
142.109

[ 闪点 ]:
176.9±16.9 °C

[ 精确质量 ]:
142.026611

[ PSA ]:
74.60000

[ LogP ]:
-0.21

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.549

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
insoluble

反式,反式-1,3-丁二烯-1,4-二羧酸MSDS

反式,反式-1,3-丁二烯-1,4-二羧酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MM2235070

CHEMICAL NAME :: 2,4-Hexadienedioic acid, (E,E)-

CAS REGISTRY NUMBER :: 3588-17-8

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H6-O4

MOLECULAR WEIGHT :: 142.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 10 mg/L

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 81,77,1989

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反式,反式-1,3-丁二烯-1,4-二羧酸安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MM2235070

[ 海关编码 ]:
2917190090

反式,反式-1,3-丁二烯-1,4-二羧酸合成路线

反式,反式-1,3-丁二烯-1,4-二羧酸上下游产品

反式,反式-1,3-丁二烯-1,4-二羧酸上游产品

反式,反式-1,3-丁二烯-1,4-二羧酸下游产品

反式,反式-1,3-丁二烯-1,4-二羧酸制备

将 3kg 氢氧化钾溶于 5L 甲醇，搅拌，滴加 1130g 热至 100 ℃ 的α,δ-二溴已二酸二乙酯。调节加料速度，使反应物较激烈地回流。加料后继续加热搅拌2h。在室温放置过夜，滤出2,4-已二烯二酸钾盐和溴化钾。将滤饼溶于 8L 热水，加 30g 活性炭煮沸，过滤。滤液冷却后加浓盐酸酸化。滤出产物，洗涤，干燥，得165 -195g 2，4-已二烯二酸。收率37%-43%。

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反式,反式-1,3-丁二烯-1,4-二羧酸海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

反式,反式-1,3-丁二烯-1,4-二羧酸文献

Influence of genetic polymorphism on t,t-MA/S-PMA ratio in 301 benzene exposed subjects.

Toxicol. Lett. 231(2) , 205-12, (2014)

This study investigated the effect of polymorphic genes GSTT1, GSTM1, GSTA1, EHPX1, NQO1, CYP2E1, CYP1A and MPO on the urinary concentrations and ratio (R) of the benzene metabolites trans,trans-mucon...

Quantitative analysis of catechol and 4-methylcatechol in human urine.

Food Chem. Toxicol. 20(5) , 587-90, (1982)

A method was developed for the quantitative analysis of catechol and 4-methylcatechol in human urine. [U-14C]Catechol was used as in internal standard. Urine was treated with beta-glucuronidase and su...

Almond consumption reduces oxidative DNA damage and lipid peroxidation in male smokers.

J. Nutr. 137(12) , 2717-22, (2007)

Smoking increases the risk of several chronic diseases associated with elevated oxidative stress status. Almonds are a good source of antioxidant nutrients and may diminish smoking-related biomarkers ...

更多文献

反式,反式-1,3-丁二烯-1,4-二羧酸

反式,反式-1,3-丁二烯-1,4-二羧酸用途

反式,反式-1,3-丁二烯-1,4-二羧酸名称

反式,反式-1,3-丁二烯-1,4-二羧酸生物活性

反式,反式-1,3-丁二烯-1,4-二羧酸物理化学性质

反式,反式-1,3-丁二烯-1,4-二羧酸MSDS

详细MSDS(安全技术说明书)

反式,反式-1,3-丁二烯-1,4-二羧酸毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

反式,反式-1,3-丁二烯-1,4-二羧酸安全信息

反式,反式-1,3-丁二烯-1,4-二羧酸合成路线

详细合成路线

反式,反式-1,3-丁二烯-1,4-二羧酸上下游产品

反式,反式-1,3-丁二烯-1,4-二羧酸上游产品

反式,反式-1,3-丁二烯-1,4-二羧酸下游产品

反式,反式-1,3-丁二烯-1,4-二羧酸制备

反式,反式-1,3-丁二烯-1,4-二羧酸海关

反式,反式-1,3-丁二烯-1,4-二羧酸文献

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