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1,1,1-三氟-2-十七烷酮

1,1,1-三氟-2-十七烷酮用途

PACOCF3(三氟棕榈酸)乙酮)是一种选择性磷脂酶A2抑制剂,IC50为3.8μM。PACOCF3改变肾小管细胞中的钙信号[1][2]。

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1,1,1-三氟-2-十七烷酮名称

[ CAS 号 ]:
141022-99-3

[ 中文名 ]:
1,1,1-三氟-2-十七烷酮

[ 英文名 ]:
PACOCF3

[英文别名 ]:

2-Heptadecanone, 1,1,1-trifluoro-
MFCD00797669
1,1,1-Trifluoro-2-heptadecanone
1,1,1-trifluoroheptadecan-2-one
PACOCF3 Pentadecyl trifluoromethyl ketone

1,1,1-三氟-2-十七烷酮生物活性

[ 描述 ]:

PACOCF3(三氟棕榈酸)乙酮)是一种选择性磷脂酶A2抑制剂,IC50为3.8μM。PACOCF3改变肾小管细胞中的钙信号[1][2]。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷脂

研究领域 >> 炎症/免疫

[ 靶点 ]

PLA2:3.8 μM (IC50)

[体外研究]

在浓度为20μM时,PACOCF3不会改变基础细胞溶质游离钙浓度([Ca2+]i),但在浓度为50-250μM时,PACOCF3通过激活细胞外Ca2+进入而诱导[Ca2+]i增加,而细胞外Ca2+进入部分被50μM La3+[2]抑制。PACOCF3的作用通过去除细胞外Ca2+而被消除。PACOCF3(10μM)通过增强细胞外Ca2+内流而不影响内部Ca2+释放,从而增强由10μM ATP和1μM缓激肽诱导的[Ca2+]i增加的峰值和曲线下面积[2]。

[参考文献]

[1]. E J Ackermann, et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 6;270(1):445-50.

[2]. C R Jan, et al. Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells. Arch Toxicol. 2000 Oct;74(8):447-51.

1,1,1-三氟-2-十七烷酮物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
329.0±37.0 °C at 760 mmHg

[ 分子式 ]:
C₁₇H₃₁F₃O

[ 分子量 ]:
308.423

[ 闪点 ]:
227.1±18.0 °C

[ 精确质量 ]:
308.232697

[ PSA ]:
17.07000

[ LogP ]:
7.93

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.418

[ 储存条件 ]:
-20°C

1,1,1-三氟-2-十七烷酮MSDS

详细MSDS(安全技术说明书)

1,1,1-三氟-2-十七烷酮安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H319

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
UN1170 - class 3 - PG 2 - Ethanol, solution

1,1,1-三氟-2-十七烷酮文献

Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones.

J. Biol. Chem. 270 , 445, (1995)

A novel Ca(2+)-independent phospholipase A2 (PLA2) has recently been purified from the murine macrophage-like cell line P388D1 (Ackermann, E. J., Kempner, E. S., and Dennis, E. A. (1994) J. Biol. Chem...

Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate.

Biochim. Biophys. Acta 1302 , 55-60, (1996)

Methyl arachidonyl fluorophosphonate (MAFP) has been recently reported to be a selective, active-site directed, irreversible inhibitor of the Group IV 85 kDa cytosolic phospholipase A2 (cPLA2). We hav...

Metabolic oxidation regulates embryonic stem cell differentiation.

Nat. Chem. Biol. 6 , 411-7, (2010)

Metabolites offer an important unexplored complementary approach to understanding the pluripotency of stem cells. Using MS-based metabolomics, we show that embryonic stem cells are characterized by ab...

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