4-(苯甲酰氧基)-1-甲基哌啶

4-(苯甲酰氧基)-1-甲基哌啶用途

Diphenylpyraline 是一种有效的组胺 H1 受体 (histamine H1 receptor) 的拮抗剂。Diphenylpyraline 是一种具有口服活性抗组胺试剂,具有抗胆碱和抗过敏作用。Diphenylpyraline 可用于过敏性疾病,包括鼻炎和花粉热,以及瘙痒性皮肤疾病等的研究。

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4-(苯甲酰氧基)-1-甲基哌啶名称

[ CAS 号 ]:
147-20-6

[ 中文名 ]:
双苯拉林

[ 英文名 ]:
diphenylpyraline

[中文别名 ]:

4-(二苯基甲氧基)-1-甲基哌啶

[英文别名 ]:

Hispril
N-methyl-4-(diphenylmethoxy)piperidine
Neargal
Lergobine
EINECS 205-686-7
Belfene
Dayfen
4-benzhydryloxy-1-methyl-piperidine
Histyn
Mepiben

4-(苯甲酰氧基)-1-甲基哌啶生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 炎症/免疫

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

[ 靶点 ]

H1 Receptor

[体外研究]

二苯基吡啉(10μM) 显著抑制小鼠伏隔核切片多巴胺摄取[2]。

[体内研究]

二苯吡啉(腹腔注射) 注入；5-10mg/kg)可提高小鼠伏隔核细胞外多巴胺水平(~200%),并诱导小鼠运动激活[2]。动物模型：C57BL/6小鼠[2]剂量：5-10mg/kg给药：腹腔注射注射结果：具有精神刺激作用。

[参考文献]

[1]. Erik B Oleson, et al. Effects of the histamine H₁ receptor antagonist and benztropine analog diphenylpyraline on dopamine uptake, locomotion and reward.

[2]. Gennady B Lapa, et al. Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties.

4-(苯甲酰氧基)-1-甲基哌啶物理化学性质

[ 密度 ]:
1.08 g/cm3

[ 沸点 ]:
378.7ºC at 760 mmHg

[ 分子式 ]:
C₁₉H₂₃NO

[ 分子量 ]:
281.39200

[ 闪点 ]:
111.6ºC

[ 精确质量 ]:
281.17800

[ PSA ]:
12.47000

[ LogP ]:
3.82470

[ 蒸汽压 ]:
6.18E-06mmHg at 25°C

[ 折射率 ]:
1.587

[ 储存条件 ]:
室温

4-(苯甲酰氧基)-1-甲基哌啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM7810000

CHEMICAL NAME :: Piperidine, 4-(diphenylmethoxy)-1-methyl-

CAS REGISTRY NUMBER :: 147-20-6

BEILSTEIN REFERENCE NO. :: 0245467

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H23-N-O

MOLECULAR WEIGHT :: 281.43

WISWESSER LINE NOTATION :: T6NTJ A1 DOYR&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 50,459,1979 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,155,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,1203,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84788 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 62 (estimated)

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4-(苯甲酰氧基)-1-甲基哌啶安全信息

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933399090

4-(苯甲酰氧基)-1-甲基哌啶上下游产品

4-(苯甲酰氧基)-1-甲基哌啶上游产品

4-(苯甲酰氧基)-1-甲基哌啶下游产品

4-(苯甲酰氧基)-1-甲基哌啶海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%