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吲哚-2-羧酸

吲哚-2-羧酸用途

Indole-2-carboxylic acid 是脂质过氧化的强效抑制剂。Indole-2-carboxylic acid (I2CA) 特异性的、竞争性的抑制甘氨酸对NMDA 门控电流的增强作用。

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吲哚-2-羧酸名称

[ CAS 号 ]:
1477-50-5

[ 中文名 ]:
2-吲哚甲酸

[ 英文名 ]:
Indole-2-carboxylic acid

[中文别名 ]:

[英文别名 ]:

1H-Indole-2-carboxylic acid
T56 BMJ CVQ
Indole-2-carboxylic acid
2-Carboxyindole
2-Indolecarboxylic acid
MFCD00005611
EINECS 216-030-4

吲哚-2-羧酸生物活性

[ 描述 ]:

Indole-2-carboxylic acid 是脂质过氧化的强效抑制剂。Indole-2-carboxylic acid (I2CA) 特异性的、竞争性的抑制甘氨酸对NMDA 门控电流的增强作用。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. 2-Indolecarboxylic acid.

[2]. J E Huettner, et al. Indole-2-carboxylic Acid: A Competitive Antagonist of Potentiation by Glycine at the NMDA Receptor. Science. 1989 Mar 24;243(4898):1611-3.

吲哚-2-羧酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
419.6±18.0 °C at 760 mmHg

[ 熔点 ]:
202-206 °C(lit.)

[ 分子式 ]:
C₉H₇NO₂

[ 分子量 ]:
161.157

[ 闪点 ]:
207.6±21.2 °C

[ 精确质量 ]:
161.047684

[ PSA ]:
53.09000

[ LogP ]:
2.31

[ 外观性状 ]:
灰白色晶体粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.726

[ 储存条件 ]:
存放于惰性气体之中;避免空气

吲哚-2-羧酸MSDS

吲哚-2-羧酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;Xn: Harmful;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NK7882812

[ 海关编码 ]:
29339990

吲哚-2-羧酸合成路线

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吲哚-2-羧酸下游产品

吲哚-2-羧酸制备

由2-硝基丙酮酸用醋酸及锌粉还原，或以2-氨基-α-甲氧基肉桂酸加热至熔点以上，然后用浓硫酸加热处理即制得本品。

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吲哚-2-羧酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吲哚-2-羧酸文献

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.

Bioorg. Med. Chem. 17 , 5219-28, (2009)

In the light of known HDAC inhibitors, 33 carboxylic acid derivatives were tested to understand the structural requirements for HDAC inhibition activity. Several modifications were applied to develop ...

In vitro and in vivo assessment of the antioxidant activity of melatonin and related indole derivatives.

Gen. Physiol. Biophys. 21(2) , 153-62, (2002)

Effects of melatonin and some structurally related indole compounds were studied by in vitro methods such as (i) an inhibition of the hyaluronic acid degradation and (ii) a standard lipid peroxidation...

Protonated carbonic acid and reactive intermediates in the acidic decarboxylation of indolecarboxylic acids.

J. Org. Chem. 77(15) , 6505-9, (2012)

Elucidation of the mechanism for decarboxylation of indolecarboxylic acids over a wide range of solution acidity reveals the importance of protonated carbonic acid (PCA) as a reaction intermediate. In...

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