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乙酰基-缬氨酰-丙氨酰-天冬氨醛

乙酰基-缬氨酰-丙氨酰-天冬氨醛用途

Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) 是一种泛半胱天冬酶 (caspase) 抑制剂。Ac-VAD-CHO 抑制缺氧细胞中 MMP 的消散和细胞色素 c 的释放。

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乙酰基-缬氨酰-丙氨酰-天冬氨醛名称

[ CAS 号 ]:
147837-52-3

[ 中文名 ]:
乙酰基-缬氨酰-丙氨酰-天冬氨醛

[ 英文名 ]:
N-Acetyl-Val-Ala-Asp-al

[英文别名 ]:

Ac-VAD-CHO
N-Acetyl-Val-Ala-Asp-al
Ac-Val-Ala-Asp-CHO
Caspase Inhibitor II

乙酰基-缬氨酰-丙氨酰-天冬氨醛生物活性

[ 描述 ]:

Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) 是一种泛半胱天冬酶 (caspase) 抑制剂。Ac-VAD-CHO 抑制缺氧细胞中 MMP 的消散和细胞色素 c 的释放。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞凋亡 >> 胱天蛋白酶

[参考文献]

[1]. Jee-Youn Kim, et al. ROS-dependent caspase-9 activation in hypoxic cell death. FEBS Lett. 2003 Aug 14;549(1-3):94-8.

乙酰基-缬氨酰-丙氨酰-天冬氨醛物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
698.2±55.0 °C at 760 mmHg

[ 分子式 ]:
C₁₄H₂₃N₃O₆

[ 分子量 ]:
329.349

[ 闪点 ]:
376.0±31.5 °C

[ 精确质量 ]:
329.158691

[ PSA ]:
141.67000

[ LogP ]:
-0.05

[ 蒸汽压 ]:
0.0±4.7 mmHg at 25°C

[ 折射率 ]:
1.498

[ 储存条件 ]:
−20°C

乙酰基-缬氨酰-丙氨酰-天冬氨醛MSDS

详细MSDS(安全技术说明书)

乙酰基-缬氨酰-丙氨酰-天冬氨醛安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

乙酰基-缬氨酰-丙氨酰-天冬氨醛文献

zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation.

Autophagy 7 , 217-228, (2011)

The treatment of L929 fibrosarcoma cells with zVAD has been shown to induce necroptosis. However, whether autophagy is involved or not in this event remains controversial. In this study, we re-examine...

Inhibition of human caspases by peptide-based and macromolecular inhibitors.

J. Biol. Chem. 273 , 32608-32613, (1998)

Studies with peptide-based and macromolecular inhibitors of the caspase family of cysteine proteases have helped to define a central role for these enzymes in inflammation and mammalian apoptosis. A c...

Caspase activation by BCR cross-linking in immature B cells: differential effects on growth arrest and apoptosis.

FASEB J. 13 , 931-944, (1999)

The B cell lymphoma WEHI-231 has been used as a model to study immature B cell tolerance, based on its capacity to undergo growth arrest and programmed cell death on B cell receptor (BCR) cross-linkin...

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