羧基-PTIO 钾盐

羧基-PTIO 钾盐用途

Carboxy-PTIO potassium 是一种有效的一氧化氮 (NO) 拮抗剂,能与 NO 快速反应产生 NO2。Carboxy-PTIO potassium 通过对脂多糖诱导大鼠模型中 NO 的直接清除作用,可预防低血压和内毒素休克。

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羧基-PTIO 钾盐名称

[ CAS 号 ]:
148819-94-7

[ 中文名 ]:
2-(4-羧基苯基)-4,4,5,5-四甲基咪唑啉-1-氧-3-氧化钾盐

[ 英文名 ]:
Carboxy-PTIO potassium

[中文别名 ]:

2-4-羧苯基四甲基咪唑烷-1-氧-3-氧化物

[英文别名 ]:

Carboxy-PTIO potassium salt
MFCD00216153
CARBOXY-PTIO

羧基-PTIO 钾盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

研究领域 >> 炎症/免疫

研究领域 >> 代谢疾病

[体外研究]

羧甲基PTIO钾(200μM；酸浆素A前1小时；24小时)显著抑制酸浆素A处理诱导的NO表达刺激,但仅在羧甲基PTIO处理中未观察到任何变化[1]。羧甲基PTIO钾(200μM；比酸浆素A早1小时；24小时)减少了酸浆素A诱导的原磷酸酶3和PARP的断裂,下调了ICAD的表达,减少了细胞核中的DNA碎片[1]。羧甲基PTIO钾(200μM；酸浆蛋白A前1小时；24小时)对iNOS表达无影响。然而,在A375-S2细胞中,由酸浆素A引起的mTOR和p-mTOR水平的降低被羧基PTIO逆转,同时抑制了lc3i到LC3-II的转化[1]。Western Blot分析[1]细胞系：A375-S2细胞浓度：200μM孵育时间：酸浆蛋白A前1h；24小时结果：酸浆素A诱导的前caspase-3和PARP裂解减少。

[体内研究]

coboxy-PTIO(静脉注射；0.056-1.70mg/kg/min；在LPS注射90min后90 min开始注射1h)可改善LPS治疗大鼠的低血压、肾功能不全和存活率。但不影响脑损伤大鼠的各项指标[3]。动物模型：SD大鼠[3]剂量：0.056-1.70mg/kg/min给药：静脉注射；0.056-1.70mg/kg/min；注射LPS 90min后90min开始静脉注射1h。结果：通过对NO的直接清除作用,对内毒素休克有很强的治疗价值。

[参考文献]

[1]. Hao He, et al.Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.Food Chem Toxicol. 2014 Sep;71:128-35.

[2]. T Akaike, et al. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction. Biochemistry. 1993 Jan 26;32(3):827-32.

[3]. M Yoshid, et al. Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity. Biochem Biophys Res Commun. 1994 Jul 29;202(2):923-30.

羧基-PTIO 钾盐物理化学性质

[ 沸点 ]:
456.3ºC at 760 mmHg

[ 熔点 ]:
141-143°C

[ 分子式 ]:
C₁₄H₁₇KN₂O₄

[ 分子量 ]:
315.386

[ 闪点 ]:
229.7ºC

[ 精确质量 ]:
315.074707

[ PSA ]:
69.29000

[ LogP ]:
1.75670

[ 外观性状 ]:
无气味的蓝色粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: >20 mg/mL

羧基-PTIO 钾盐MSDS

详细MSDS(安全技术说明书)

羧基-PTIO 钾盐安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

羧基-PTIO 钾盐文献

Molecules involve in the self-protection of neurons against glucose-oxygen-serum deprivation (GOSD)-induced cell damage.

Brain Res. Bull. 79 , 169-76, (2009)

Molecules involved in self-protection of neurons against glucose/oxygen/serum deprivation (GOSD) were investigated. Trypan blue dye exclusion assay, Western blotting, ELISA, cytokine antibody array an...

Dietary supplementation with sodium nitrite can exert neuroprotective effects on global cerebral ischemia/reperfusion in mice.

J. Anesth. 29 , 609-17, (2015)

Nitrite-derived NO protects against middle cerebral artery occlusion in mice. We developed a new mouse model of global cerebral ischemia and reperfusion (GCI/R) involving reversible occlusion of the m...

Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.NO through a radical reaction.

Biochemistry 32 , 827, (1993)

A labile inorganic free radical, nitric oxide (.NO), is produced by nitric oxide synthase from the substrate L-arginine in various cells and tissues. It acts as an endothelium-derived relaxing factor ...

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