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硫酸魁蛤素

硫酸魁蛤素用途

Arcaine (sulfate) 是一种谷氨酸 NMDA 受体抑制剂。

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硫酸魁蛤素名称

[ CAS 号 ]:
14923-17-2

[ 中文名 ]:
魁蛤素硫酸盐

[ 英文名 ]:
Arcaine sulfate

[中文别名 ]:

硫酸魁蛤素

[英文别名 ]:

1,4-DIGUANIDINOBUTANE SULFATE SALT
ARCAINE SULPHATE
1,4-diguanidinobutane sulfate
N,N'''-butanediyl-di-guanidine,sulfate
ARCAIN SULFATE
MFCD00050545
N,N'''-Butandiyl-di-guanidin,Sulfat
ARCAINE SULFATE SALT
Butane-1,4-diguanidium sulfate
1,1'-tetramethylenediguanidine sulphate

硫酸魁蛤素生物活性

[ 描述 ]:

Arcaine (sulfate) 是一种谷氨酸 NMDA 受体抑制剂。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[参考文献]

[1]. Huang MJ, et al. Structure-activity analysis of guanidine group in agmatine for brain agmatinase. Ann N Y Acad Sci. 2003 Dec;1009:52-63.

硫酸魁蛤素物理化学性质

[ 密度 ]:
1.37g/cm3

[ 沸点 ]:
408.9ºC at 760mmHg

[ 熔点 ]:
291°C (dec.)

[ 分子式 ]:
C₆H₁₈N₆O₄S

[ 分子量 ]:
270.31

[ 闪点 ]:
201.1ºC

[ 精确质量 ]:
270.11100

[ PSA ]:
206.78000

[ LogP ]:
1.54260

[ 蒸汽压 ]:
6.76E-07mmHg at 25°C

[ 储存条件 ]:
Store at RT

硫酸魁蛤素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF6550000

CAS REGISTRY NUMBER :: 14923-17-2

LAST UPDATED :: 199012

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H16-N6.H2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

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硫酸魁蛤素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MF6550000

[ 海关编码 ]:
2925290090

硫酸魁蛤素合成路线

详细合成路线

硫酸魁蛤素上下游产品

硫酸魁蛤素上游产品

硫酸魁蛤素下游产品

硫酸魁蛤素海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

硫酸魁蛤素文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Peripheral and central routes of administration of quaternary ammonium compound IEM-1460 are equally potent in reducing the severity of nicotine-induced seizures in mice.

Bull. Exp. Biol. Med. 146(1) , 18-21, (2008)

Peripheral administration of nicotinic receptor antagonists with a quaternary ammonium group (hexamethonium and chlorisondamine) did not prevent the development of seizures induced by systemic treatme...

Spermidine decreases Na+,K+-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats

Eur. J. Pharmacol. 684(1-3) , 79-86, (2012)

Spermidine is an endogenous polyamine with a polycationic structure present in the central nervous system of mammals. Spermidine regulates biological processes, such as Ca2+ influx by glutamatergic N-...

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