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磺胺林

磺胺林用途

Sulfalene 是一种抗疟药。
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磺胺林名称

[ CAS 号 ]:
152-47-6

[ 中文名 ]:
磺胺林

[ 英文名 ]:
sulfalene

[中文别名 ]:

[英文别名 ]:

磺胺林生物活性

[ 描述 ]:

Sulfalene 是一种抗疟药。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物
研究领域 >> 感染

[ 靶点 ]

Parasite[1]


[参考文献]

[1]. Obonyo CO, et al. Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial. Lancet Infect Dis. 2010 Sep;10(9):603-11.


[相关活性小分子]

硫酸羟基氯喹 | 甲硝唑 | Emetine dihydrochloride hydrate | 伊维菌素 | 青蒿素 | 盐酸左旋咪唑 | 氟雷拉纳 | RRX-001 | 阿维菌素 | 奎尼丁 | 硫双二氯酚 | 氟苯咪唑 | 甲苯咪唑 | SQ109 | 蒿甲醚

磺胺林物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
488.6±55.0 °C at 760 mmHg

[ 熔点 ]:
270 °C (dec.)(lit.)

[ 分子式 ]:
C11H12N4O3S

[ 分子量 ]:
280.303

[ 闪点 ]:
249.3±31.5 °C

[ 精确质量 ]:
280.063019

[ PSA ]:
115.58000

[ LogP ]:
1.10

[ 外观性状 ]:
白色或略黄色晶体粉末

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.647

[ 储存条件 ]:
室温

[ 水溶解性 ]:
微溶：甲醇

磺胺林MSDS

详细MSDS(安全技术说明书)

磺胺林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WP0175000
CHEMICAL NAME :
Sulfanilamide, N(sup 1)-(3-methoxypyrazinyl)-
CAS REGISTRY NUMBER :
152-47-6
BEILSTEIN REFERENCE NO. :
0622512
LAST UPDATED :
199612
DATA ITEMS CITED :
17
MOLECULAR FORMULA :
C11-H12-N4-O3-S
MOLECULAR WEIGHT :
280.33
WISWESSER LINE NOTATION :
T6N DNJ BO1 CMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2739 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1790 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1292 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1590 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
893 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
132 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
46 gm/kg/33W-C
TOXIC EFFECTS :
Endocrine - thyroid weight (goiter) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11200 ug/kg/14D-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4200 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
300 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1800 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
12 gm/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
300 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3 gm/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction
TEST SYSTEM :
Mold - Aspergillus nidulans
DOSE/DURATION :
1 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974
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磺胺林安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36

[ WGK德国 ]:
3

[ 海关编码 ]:
2935009090

磺胺林合成路线

详细合成路线

磺胺林上下游产品

磺胺林上游产品

磺胺林下游产品

磺胺林海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

相关化工产品/化学物质：

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐乾明

产品详情：磺胺林

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥1128.0/5g

联系人：刘佳

产品详情：磺胺林

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：AS-18908

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥123.9/1g ￥582.9/25g ￥168.9/5g ￥514.9/1ml

联系人：阿拉丁

产品详情：磺胺林

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥1979.0/25g ￥275.0/1g ￥831.0/5g

联系人：夏言

产品详情：[Perfemiker]磺胺林,≥98%

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相关化合物

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