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萘格列酮

萘格列酮用途

奈格列酮是PPARα和PPARγ的双重激动剂,具有降血糖活性[1]。

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萘格列酮名称

[ CAS 号 ]:
161600-01-7

[ 中文名 ]:
萘格列酮

[ 英文名 ]:
netoglitazone

[英文别名 ]:

UNII-QOV2JZ647A
Isaglitazone
MCC-555
netoglitazone

萘格列酮生物活性

[ 描述 ]:

奈格列酮是PPARα和PPARγ的双重激动剂,具有降血糖活性[1]。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> PPAR

研究领域 >> 代谢疾病

[ 靶点 ]

PPARα

PPARγ

[参考文献]

[1]. Reginato MJ, et al. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. J Biol Chem. 1998 Dec 4;273(49):32679-84.

萘格列酮物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
599.5±30.0 °C at 760 mmHg

[ 分子式 ]:
C₂₁H₁₆FNO₃S

[ 分子量 ]:
381.420

[ 闪点 ]:
316.4±24.6 °C

[ 精确质量 ]:
381.083496

[ PSA ]:
80.70000

[ LogP ]:
4.50

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.668

[ 储存条件 ]:
2-8°C

萘格列酮安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
50/53

[ 安全声明 (欧洲) ]:
60-61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ RTECS号 ]:
XJ5813445

萘格列酮合成路线

详细合成路线

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萘格列酮文献

MCC-555-induced NAG-1 expression is mediated in part by KLF4.

Eur. J. Pharmacol. 637(1-3) , 30-7, (2010)

Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a central role in cell differentiation, metabolism and tumorigenesis. We have investigated the therapeutic properties of 5-[[6-[(2-fl...

Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat.

Int. J. Exp. Pathol. 84(2) , 83-9, (2003)

The Zucker Diabetic Fatty (ZDF) rat is a model of impaired insulin sensitivity arising from hyperphagia owing to a mutation in the leptin receptor. In time, young ZDF rats, which are not initially dia...

Activation of PPARgamma is not involved in butyrate-induced epithelial cell differentiation.

Exp. Cell Res. 310(1) , 196-204, (2005)

Histone deacetylase-inhibitors affect growth and differentiation of intestinal epithelial cells by inducing expression of several transcription factors, e.g. Peroxisome proliferator-activated receptor...

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