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2,4-噻唑烷二酮

2,4-噻唑烷二酮用途

2,4-噻唑烷二酮是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

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2,4-噻唑烷二酮名称

[ CAS 号 ]:
2295-31-0

[ 中文名 ]:
2,4-噻唑烷二酮

[ 英文名 ]:
2,4-Thiazolidinedione

[中文别名 ]:

[英文别名 ]:

EINECS 218-941-2
2(5H)-Thiazolone, 4-hydroxy-
2,4-Thiazolidindione
usafek-5496
2,4-dioxothiazolidine
Thiazolidinedione
2,4-Thiazolidinedione
1,3-Thiazolidine-2,4-dione
2-thiazolidin-4-one
2,4-thiazolidinone

2,4-噻唑烷二酮生物活性

[ 描述 ]:

2,4-噻唑烷二酮是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

PPARγ激动剂。胰岛素增敏剂。

2,4-噻唑烷二酮物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
178-179 ºC (19 mmHg)

[ 熔点 ]:
123-126 ºC

[ 分子式 ]:
C₃H₃NO₂S

[ 分子量 ]:
117.13

[ 闪点 ]:
138.7±19.3 °C

[ 精确质量 ]:
116.988449

[ PSA ]:
71.47000

[ LogP ]:
-0.54

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.577

[ 储存条件 ]:
存放于惰性气体之中;避免空气

[ 水溶解性 ]:
水溶性：可溶；可溶于：乙醇

2,4-噻唑烷二酮MSDS

2,4-噻唑烷二酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ5775000

CHEMICAL NAME :: 2,4-Thiazolidinedione

CAS REGISTRY NUMBER :: 2295-31-0

BEILSTEIN REFERENCE NO. :: 0110700

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C3-H3-N-O2-S

MOLECULAR WEIGHT :: 117.13

WISWESSER LINE NOTATION :: T5SVMV EHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 9,274,1954

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2,4-噻唑烷二酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
XJ5775000

[ 海关编码 ]:
2942000000

2,4-噻唑烷二酮合成路线

2,4-噻唑烷二酮上下游产品

2,4-噻唑烷二酮上游产品

2,4-噻唑烷二酮下游产品

2,4-噻唑烷二酮海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2,4-噻唑烷二酮文献

Cytotoxicity of thiazolidinedione-, oxazolidinedione- and pyrrolidinedione-ring containing compounds in HepG2 cells.

Toxicol. In Vitro 29 , 1887-96, (2015)

Liver damage occurred in some patients who took troglitazone (TGZ) for type II diabetes. The 2,4-thiazolidinedione (TZD) ring in TGZ's structure has been implicated in its hepatotoxicity. To further e...

Differential cardiovascular outcomes after dipeptidyl peptidase-4 inhibitor, sulfonylurea, and pioglitazone therapy, all in combination with metformin, for type 2 diabetes: a population-based cohort study.

PLoS ONE 10 , e0124287, (2015)

Data on the comparative effectiveness of oral antidiabetics on cardiovascular outcomes in a clinical practice setting are limited. This study sought to determine whether a differential risk of cardiov...

Effects of Various 5,7-Dihydroxyflavone Analogs on Adipogenesis in 3T3-L1 Cells.

Biol. Pharm. Bull. 38 , 1794-800, (2015)

We studied the effects of twelve 5,7-dihydroxyflavone analogs on adipogenesis in 3T3-L1 cells. Among the compounds, luteolin, diosmetin, and chrysoeriol partly inhibited adipogenesis by blocking the a...

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