nereistoxin

nereistoxin用途

耐雷氏毒素(Nereistoxine)是一种从海洋环节动物异齿蚓中分离出来的神经毒素,通过阻断烟碱乙酰胆碱受体发挥作用[1]。

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nereistoxin名称

[ CAS 号 ]:
1631-58-9

[ 英文名 ]:
nereistoxin

[英文别名 ]:

[1,2]dithiolan-4-yl-dimethyl-amine
Nercistoxin
DSOOGBGKEWZRIH-UHFFFAOYSA
N,N-Dimethyl-1,2-dithiolan-4-amine
N,N-dimethyldithiolan-4-amine
Nereistoxin
4-Dimethylamino-1,2-dithiolan
1,2-DITHIOLAN-4-AMINE,N,N-DIMETHYL
4-(N,N-dimethylamino)-1,2-dithiolane

nereistoxin生物活性

[ 描述 ]:

耐雷氏毒素(Nereistoxine)是一种从海洋环节动物异齿蚓中分离出来的神经毒素,通过阻断烟碱乙酰胆碱受体发挥作用[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 胆碱受体

信号通路 >> 神经信号通路 >> 胆碱受体

研究领域 >> 神经疾病

[参考文献]

[1]. S Chiba, et al. Nereistoxin and its derivatives, their neuromuscular blocking and convulsive actions. Jpn J Pharmacol. 1967 Sep;17(3):491-2.

nereistoxin物理化学性质

[ 密度 ]:
1.16 g/cm3

[ 沸点 ]:
209.3ºC at 760 mmHg

[ 分子式 ]:
C₅H₁₁NS₂

[ 分子量 ]:
149.27800

[ 闪点 ]:
80.4ºC

[ 精确质量 ]:
149.03300

[ PSA ]:
53.84000

[ LogP ]:
1.31160

nereistoxin毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JP0470000

CHEMICAL NAME :: 1,2-Dithiolan-4-amine, N,N-dimethyl-

CAS REGISTRY NUMBER :: 1631-58-9

BEILSTEIN REFERENCE NO. :: 1421129

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C5-H11-N-S2

MOLECULAR WEIGHT :: 149.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 92600 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known. Volume(issue)/page/year: 21,149,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976- Volume(issue)/page/year: 26,117,1986

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nereistoxin安全信息

[ 海关编码 ]:
2934999090

nereistoxin合成路线

详细合成路线

nereistoxin上下游产品

nereistoxin上游产品

nereistoxin下游产品

nereistoxin海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%