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L-半胱氨酸S-硫酸盐

L-半胱氨酸S-硫酸盐用途

L-半胱氨酸S-硫酸盐是一种有效的N-甲基-d-天冬氨酸(NMDA)谷氨酸受体激动剂。L-半胱氨酸S-硫酸盐是半胱氨酸裂解酶的底物[1]。

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L-半胱氨酸S-硫酸盐名称

[ CAS 号 ]:
1637-71-4

[ 中文名 ]:
S-磺基-L-半胱氨酸

[ 英文名 ]:
S-sulfo-L-cysteine

[英文别名 ]:

S-Sulfocysteine
S-sulpho-L-cysteine
Cysteinyl-S-sulfonate
S-Sulfo-L-cystein
S-Sulphocysteine
L-Cysteine S-sulfate
(2R)-2-amino-3-sulfosulfanylpropanoic acid
Cysteine-S-sulfonate
S-Sulfo-L-cysteine
Cysteine-S-sulfate

L-半胱氨酸S-硫酸盐生物活性

[ 描述 ]:

L-半胱氨酸S-硫酸盐是一种有效的N-甲基-d-天冬氨酸(NMDA)谷氨酸受体激动剂。L-半胱氨酸S-硫酸盐是半胱氨酸裂解酶的底物[1]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Steventon GB, et, al. Comparison of the sulfur-oxygenation of cysteine and S-carboxymethyl-l-cysteine in human hepatic cytosol and the rôle of cysteine dioxygenase. J Pharm Pharmacol. 2018 Aug;70(8):1069-1077.

L-半胱氨酸S-硫酸盐物理化学性质

[ 熔点 ]:
184-185ºC

[ 分子式 ]:
C₃H₇NO₅S₂

[ 分子量 ]:
201.22100

[ 精确质量 ]:
200.97700

[ PSA ]:
151.37000

[ LogP ]:
0.71540

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.604

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
Store in Freezer at -20°C

[ 水溶解性 ]:
H2O: 20 mg/mL, clear, colorless

L-半胱氨酸S-硫酸盐MSDS

L-半胱氨酸S-硫酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2930909090

L-半胱氨酸S-硫酸盐合成路线

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L-半胱氨酸S-硫酸盐海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

L-半胱氨酸S-硫酸盐文献

Dietary therapy in two patients with a mild form of sulphite oxidase deficiency. Evidence for clinical and biological improvement.

J. Inherit. Metab. Dis. 23(1) , 45-53, (2000)

We report an attempt at dietetic therapy in two unrelated patients with isolated sulphite oxidase deficiency, with a mild clinical course and late onset of symptoms. In case 1, disease started at 15 m...

Urinary AASA excretion is elevated in patients with molybdenum cofactor deficiency and isolated sulphite oxidase deficiency.

J. Inherit. Metab. Dis. 35(6) , 1031-6, (2012)

Analysis of α-aminoadipic semialdehyde is an important tool in the diagnosis of antiquitin deficiency (pyridoxine-dependent epilepsy). However continuing use of this test has revealed that elevated ur...

Molybdenum cofactor deficiency: metabolic link between taurine and S-sulfocysteine.

Adv. Exp. Med. Biol. 776 , 13-9, (2013)

Molybdenum cofactor deficiency (MoCD) is a rare inherited metabolic disorder characterized by severe and progressive neurologic damage mainly caused by the loss of sulfite oxidase activity. Elevated u...

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