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3-羟基扁桃酸

3-羟基扁桃酸用途

3-Hydroxymandelic Acid 是 Phenylephrine 的代谢物,Phenylephrine 是 α 受体 (α-receptor) 的激动剂。

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3-羟基扁桃酸名称

[ CAS 号 ]:
17119-15-2

[ 中文名 ]:
3-羟基扁桃酸

[ 英文名 ]:
3-Hydroxymandelic Acid

[英文别名 ]:

3-Hydroxy-mandelsaeure
3-Hydroxymandelic Acid
EINECS 241-182-3
M-hydroxymandelate
MFCD00042723
m-Hydroxymandelic acid
MHMA
3-Hydroxyphenylglycolic acid
2-hydroxy-2-(3-hydroxyphenyl)acetic acid

3-羟基扁桃酸生物活性

[ 描述 ]:

3-Hydroxymandelic Acid 是 Phenylephrine 的代谢物,Phenylephrine 是 α 受体 (α-receptor) 的激动剂。

[ 相关类别 ]:

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

去甲肾上腺素是一种α-受体激动剂,在人体内被代谢成间羟基苯乙二醇(MHPG)和间羟基扁桃酸(MHMA)[1]。尿MHMA可能来源于间-章鱼胺或间-肾上腺素(去氧肾上腺素)或两者兼而有之[1]。

[参考文献]

[1]. Gumbhir K, et al. Determination of m-hydroxymandelic acid, m-hydroxyphenylglycol and their conjugates in human plasma using liquid chromatography with electrochemical detection. J Pharm Biomed Anal. 1994 Jul;12(7):943-9.

[2]. Crowley JR, et al. Normal excretion of m-hydroxymandelic acid in hypertensive patients. Clin Chim Acta. 1981 Jan 22;109(2):125-31.

[相关活性小分子]

3-羟基扁桃酸物理化学性质

[ 密度 ]:
1.48g/cm3

[ 沸点 ]:
424.3ºC at 760mmHg

[ 熔点 ]:
128-132ºC

[ 分子式 ]:
C₈H₈O₄

[ 分子量 ]:
168.14700

[ 闪点 ]:
224.5ºC

[ 精确质量 ]:
168.04200

[ PSA ]:
77.76000

[ LogP ]:
0.51020

[ 蒸汽压 ]:
5.91E-08mmHg at 25°C

[ 折射率 ]:
1.637

[ 储存条件 ]:
室温，密封，干燥

3-羟基扁桃酸MSDS

3-羟基扁桃酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918290000

3-羟基扁桃酸合成路线

3-羟基扁桃酸上下游产品

3-羟基扁桃酸上游产品

3-羟基扁桃酸下游产品

3-羟基扁桃酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

3-羟基扁桃酸文献

Improving the serum D-xylose test for the identification of patients with small intestinal malabsorption.

J. Clin. Gastroenterol. 33(1) , 36-40, (2001)

D-Xylose absorption testing is a simple, low-cost method of screening for small intestinal malabsorption. The optimum method to measure D-xylose absorption (serum vs. urine testing) is uncertain.We pr...

Plasma amino acid profile on nocturnal hemodialysis.

Blood Purif. 18(2) , 97-102, (2000)

The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile.In a cross-over trial, we studied the AA profile in 11 patients who were switched f...

Plasma pteridine concentrations in patients with chronic renal failure.

Nephrol. Dial. Transplant. 17(6) , 1032-6, (2002)

Pteridine metabolism is impaired in the uraemic state. This may affect cardiovascular function and contribute to malnutrition. We wished to clarify further the impact of impaired pteridine metabolism....

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