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1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮

1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮用途

倍半富马酸氧曲莫林是一种主要激活M2受体的mAChR激动剂。倍半富马酸氧曲莫林可用于神经学研究[1][2]。

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1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮名称

[ CAS 号 ]:
17360-35-9

[ 中文名 ]:
1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮

[ 英文名 ]:
Oxotremorine sesquifumarate

[英文别名 ]:

EINECS 241-388-3
MFCD00013163

1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮生物活性

[ 描述 ]:

倍半富马酸氧曲莫林是一种主要激活M2受体的mAChR激动剂。倍半富马酸氧曲莫林可用于神经学研究[1][2]。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 神经疾病

[体外研究]

Oxotremorine(10.5μM)对大鼠膈肌在体外对直接和间接刺激的抽搐反应产生麻痹作用[1]。

[体内研究]

在坐骨神经损伤大鼠中,Oxotremorine(10,5,21μg；10μL)i.t.剂量依赖性地抑制触觉敏感性[2]。

[参考文献]

[1]. M Das, D K Ganguly, et al. Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve. Br J Pharmacol. 1978 Feb;62(2):195-8.

[2]. Zhiyang Song, et al. Muscarinic receptor activation potentiates the effect of spinal cord stimulation on pain-related behavior in rats with mononeuropathy. Neurosci Lett. 2008 May 2;436(1):7-12.

1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮物理化学性质

[ 沸点 ]:
373.9ºC at 760 mmHg

[ 熔点 ]:
102-105ºC(lit.)

[ 分子式 ]:
C₃₆H₄₈N₄O₁₄

[ 分子量 ]:
760.78500

[ 闪点 ]:
169.1ºC

[ 精确质量 ]:
760.31700

[ PSA ]:
270.90000

[ LogP ]:
0.30300

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
8.7E-06mmHg at 25°C

[ 储存条件 ]:
2-8°C，密封，干燥

1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮MSDS

详细MSDS(安全技术说明书)

1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY6000000

CHEMICAL NAME :: 2-Pyrrolidinone, 1-(4-(1-pyrrolidinyl)-2-butynyl)-, sesquifumarate

CAS REGISTRY NUMBER :: 17360-35-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H18-N2-O.3/2C4-H4-O4

MOLECULAR WEIGHT :: 380.44

WISWESSER LINE NOTATION :: T5NVTJ A2UU2- AT5NTJ &QV1U1VQ -C

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 28,227,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#04243 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg/7D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases

REFERENCE :: DTESD7 52 Vanderbilt Ave., New York, NY 10017) V.1-15, 1977-87. Discontinued 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 11,495,1983

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1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H310-H330

[ 警示性声明 ]:
P260-P264-P280-P284-P302 + P350-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+

[ 风险声明 (欧洲) ]:
26/27/28

[ 安全声明 (欧洲) ]:
S28;S45;S36/S37

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
UY6000000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

1-(4-[1-吡咯烷基]-2-丁炔基)-2-吡咯烷酮文献

Acetylcholine activity in selective striatal regions supports behavioral flexibility.

Neurobiol. Learn. Mem. 91(1) , 13-22, (2009)

Daily living often requires individuals to flexibly respond to new circumstances. There is considerable evidence that the striatum is part of a larger neural network that supports flexible adaptations...

Stress-induced immobility in rats with cholinergic supersensitivity.

Biol. Psychiatry 21(7) , 657-64, (1986)

Immobility during forced swimming or after mild footshock (1 mA for 2 sec) was observed in five groups of rats. The Flinders Sensitive Line (FSL) of rats, known to be more sensitive to cholinergic ago...

Memory-modulatory effects of centrally acting noradrenergic drugs: possible involvement of brain cholinergic mechanisms.

Behav. Neural Biol 57(3) , 248-55, (1992)

Post-training administration of the centrally acting muscarinic agonist oxotremorine (50.0 microgram/kg, ip) facilitated 48-hr retention, in mice, of a one-trial step-through inhibitory avoidance resp...

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