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22(R)-羟基胆固醇

22(R)-羟基胆固醇用途

22(R)-Hydroxycholesterol (Narthesterol) 是一种内源性的 LXR 激动剂。22(R)-Hydroxycholesterol (Narthesterol) 可用于丹吉尔病的研究。

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22(R)-羟基胆固醇名称

[ CAS 号 ]:
17954-98-2

[ 中文名 ]:
22(R)-羟基胆固醇

[ 英文名 ]:
22-alpha-Hydroxy Cholesterol

[中文别名 ]:

[英文别名 ]:

Narthesterol
22BF-HYDROXYCHOLESTEROL
22(S)-hydroxycholesterol
(3β,22S)-Cholest-5-ene-3,22-diol
22BETA-HYDROXYCHOLESTEROL
Cholest-5-ene-3,22-diol, (3β,22S)-
22R-OHC
22(R)-HYDROXYCHOLESTEROL

22(R)-羟基胆固醇生物活性

[ 描述 ]:

22(R)-Hydroxycholesterol (Narthesterol) 是一种内源性的 LXR 激动剂。22(R)-Hydroxycholesterol (Narthesterol) 可用于丹吉尔病的研究。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> LXR

研究领域 >> 代谢疾病

[参考文献]

[1]. Costet P, et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem. 2000 Sep 8;275(36):28240-5.

22(R)-羟基胆固醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
513.1±23.0 °C at 760 mmHg

[ 分子式 ]:
C₂₇H₄₆O₂

[ 分子量 ]:
402.65

[ 闪点 ]:
213.5±17.2 °C

[ 精确质量 ]:
402.349792

[ PSA ]:
40.46000

[ LogP ]:
7.66

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.536

22(R)-羟基胆固醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

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22(R)-羟基胆固醇文献

Oxysterols synergize with statins by inhibiting SREBP-2 in ovarian cancer cells.

Gynecol. Oncol. 135(2) , 333-41, (2014)

Determine mechanisms responsible for enhanced statin efficacy in a novel statin combination we name STOX (STatin-OXysterol).Ovarian cancer cell lines were treated with combinations of statins and oxys...

HBCDD-induced sustained reduction in mitochondrial membrane potential, ATP and steroidogenesis in peripubertal rat Leydig cells.

Toxicol. Appl. Pharmacol. 282(1) , 20-9, (2015)

Hexabromocyclododecane (HBCDD), a brominated flame retardant added to various consumer products, is a ubiquitous environmental contaminant. We have previously shown that 6-hour exposure to HBCDD distu...

Tumor necrosis factor alpha may act as an intraovarian mediator of luteinizing hormone-induced oocyte maturation in trout.

Biol. Reprod. 86(1) , 1-12, (2012)

In fish, like in other vertebrates, luteinizing hormone (Lh) is an essential hormone for the completion of oocyte maturation. In salmonid fish (i.e., salmon and trout), oocyte maturation is induced by...

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