< 生产厂家价格 >

黄肉楠碱

黄肉楠碱用途

Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖,诱导自噬和凋亡。Actein 在体内几乎没有毒性。

点击显示

黄肉楠碱名称

[ CAS 号 ]:
18642-44-9

[ 中文名 ]:
黄肉楠碱

[ 英文名 ]:
Actein

[英文别名 ]:

黄肉楠碱生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 自噬 >> 自噬

信号通路 >> PI3K/Akt/mTOR 信号通路 >> AKT

信号通路 >> MAPK/ERK信号通路 >> JNK

[参考文献]

[1]. Yang ZC, et al. Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1177-1183.

[2]. Ji L, et al. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. 2017 Nov 1;8(68):112498-112515.

黄肉楠碱物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 熔点 ]:
246-250ºC

[ 分子式 ]:
C₃₇H₅₆O₁₁

[ 分子量 ]:
676.834

[ 精确质量 ]:
676.382263

[ PSA ]:
156.67000

[ LogP ]:
5.67

[ 外观性状 ]:
棕色粉末

[ 折射率 ]:
1.610

[ 储存条件 ]:
2-8℃，干燥，密闭

黄肉楠碱安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

黄肉楠碱文献

Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa.

J. Nat. Prod. 73(12) , 2024-8, (2010)

Black cohosh (Actaea racemosa) is a frequently used herbal remedy for the treatment of mild climacteric symptoms. In the present study, the modulation of γ-aminobutryic acid (GABA)-induced chloride cu...

Growth inhibitory activity of extracts and compounds from Cimicifuga species on human breast cancer cells.

Phytomedicine 15(6-7) , 504-11, (2008)

The purpose of this report is to explore the growth inhibitory effect of extracts and compounds from black cohosh and related Cimicifuga species on human breast cancer cells and to determine the natur...

Studies on the Chinese crude drug "shoma." IX. Three novel cyclolanostanol xylosides, cimicifugosides H-1, H-2 and H-5, from cimicifuga rhizome.

Chem. Pharm. Bull. 43(5) , 771-6, (1995)

Three new cyclolanostanol xylosides were isolated from a batch of commercial Cimicifuga Rhizome, cimicifugoside H-1 (1), C35H52O9, mp 260-262 degrees C, [alpha]D -43.5 degrees, cimicifugoside H-2 (2),...

更多文献