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皮质抑素-14

皮质抑素-14用途

Cortistatin-14 是一种与生长抑素-14结构相似的神经肽,通过生长抑素受体 (sst1-sst5) 结合并发挥作用。Cortistatin-14具有抗惊厥、神经保护作用和显著的抗炎作用。

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皮质抑素-14名称

[ CAS 号 ]:
186901-48-4

[ 中文名 ]:
皮质抑素-14

[ 英文名 ]:
Cortistatin 14

[英文别名 ]:

cortistatin14
Cortistatin 14

皮质抑素-14生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 生长抑素受体

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[参考文献]

[1]. De Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5.

[2]. Baranowska B, et al. Cortistatin and pituitary hormone secretion in rat. J Physiol Pharmacol. 2009 Mar;60(1):151-6.

[3]. Braun H, et al. Protective effects of cortistatin (CST-14) against kainate-induced neurotoxicity in rat brain. Brain Res. 1998 Aug 24;803(1-2):54-60.

[4]. Markovics A, et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci. 2012 Jan;46(1):40-50.

皮质抑素-14物理化学性质

[ 分子式 ]:
C₈₁H₁₁₄N₂₀O₁₈S₂

[ 分子量 ]:
1721.01000

[ 精确质量 ]:
1719.79000

[ PSA ]:
675.86000

[ LogP ]:
3.12890

[ 储存条件 ]:
−20°C

皮质抑素-14安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

皮质抑素-14文献

The cortical neuropeptide, cortistatin-14, impairs post-training memory processing.

Brain Res. 775 , 250-252, (1997)

Cortistatin-14, a neuropeptide, is present primarily in the cortex and hippocampus. In the hippocampus, cortistatin-14 inhibits pyramidal cell firing and co-exists with GABA. To determine if cortistat...

Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions.

Brain Res. Brain Res. Rev. 33 , 228-241, (2000)

Cortistatin is a recently discovered neuropeptide relative of somatostatin named after its predominantly cortical expression and ability to depress cortical activity. Cortistatin-14 shares 11 of the 1...

Structural and compositional determinants of cortistatin activity.

J. Neurosci. 56 , 611-619, (1999)

Cortistatin-14 (CST-14) is a putative novel neuropeptide that shares 11 of its 14 residues with somatostatin-14 (SRIF-14), yet its effects on sleep physiology, locomotor behavior and hippocampal funct...

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