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二氢辣椒素

二氢辣椒素用途

Dihydrocapsaicin 是一种天然辣椒素,为选择性的 TRPV1 激动剂,同时可以增加 p-Akt 水平。Dihydrocapsaicin 可以增强低温诱导的神经保护。

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二氢辣椒素名称

[ CAS 号 ]:
19408-84-5

[ 中文名 ]:
二氢辣椒碱

[ 英文名 ]:
Dihydrocapsaicin

[中文别名 ]:

[英文别名 ]:

N-(4-Hydroxy-3-methoxybenzyl)-8-methylnonanamide
6,7-Dihydrocapsaicin
8-methyl-nonanoic acid vanillylamide
Nonanamide,8-methyl-N-vanillyl
Dihydro Capsaicin
MFCD00017259
8-Methyl-N-vanillyl-nonamide
Dihydrocapsaicin
Nonanamide, 8-methyl-N-vanillyl-
EINECS 206-969-8

二氢辣椒素生物活性

[ 描述 ]:

Dihydrocapsaicin 是一种天然辣椒素,为选择性的 TRPV1 激动剂,同时可以增加 p-Akt 水平。Dihydrocapsaicin 可以增强低温诱导的神经保护。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> TRP频道

[参考文献]

[1]. Gao F, et al. Impairment in function and expression of transient receptor potential vanilloid type 4 in Dahl salt-sensitive rats: significance and mechanism. Hypertension. 2010 Apr;55(4):1018-25.

[2]. Dihydrocapsaicin, et al. Dihydrocapsaicin (DHC) enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat. Brain Res. 2017 Sep 15;1671:18-25.

二氢辣椒素物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
457.3±55.0 °C at 760 mmHg

[ 熔点 ]:
62-65 °C(lit.)

[ 分子式 ]:
C₁₈H₂₉NO₃

[ 分子量 ]:
307.428

[ 闪点 ]:
230.4±31.5 °C

[ 精确质量 ]:
307.214752

[ PSA ]:
58.56000

[ LogP ]:
4.72

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.508

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: insoluble

二氢辣椒素MSDS

详细MSDS(安全技术说明书)

二氢辣椒素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA5998000

CHEMICAL NAME :: Nonanamide, 8-methyl-N-vanillyl-

CAS REGISTRY NUMBER :: 19408-84-5

BEILSTEIN REFERENCE NO. :: 2815150

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H29-N-O3

MOLECULAR WEIGHT :: 307.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 5 mg/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 48,109,1989

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二氢辣椒素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R25;R36/37/38

[ 安全声明 (欧洲) ]:
S22-S26-S28-S36/39-S45-S36/37/39

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
RA8530000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
3302109090

二氢辣椒素上下游产品

二氢辣椒素上游产品

二氢辣椒素下游产品

二氢辣椒素海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

二氢辣椒素文献

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.

Life Sci. 92(6-7) , 368-78, (2013)

Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. The purpose of th...

Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation.

J. Pharm. Biomed. Anal. 60 , 51-8, (2012)

Capsaicinoids, salicylic acid, methyl and ethyl salicylate, glycol monosalicylate, camphor and l-menthol are widely used in topical formulations to relieve local pain. For each separate compound or si...

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