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邻氯苯乙酮

邻氯苯乙酮用途

【用途一】
用作医药中间体
【用途二】
本品用于合成支气管扩张药盐酸氯丙那林（氯喘）及其他精细化学品等。

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邻氯苯乙酮名称

[ CAS 号 ]:
2142-68-9

[ 中文名 ]:
2'-氯苯基乙酮

[ 英文名 ]:
o-Chloroacetophenone

[中文别名 ]:

[英文别名 ]:

1-(2-Chlorophenyl)ethanone
Acetophenone,2'-chloro
2’-Chloroacetophenone
o-Chloroacetophonone
Ethanone, 1- (2-chlorophenyl)-
2′-Chloroacetophenone
o-Chloroacetophenone
acetophenone, 2'-chloro-
o-chlorophenyl methyl ketone
EINECS 218-397-6

邻氯苯乙酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
195.5±13.0 °C at 760 mmHg

[ 熔点 ]:
52-56ºC

[ 分子式 ]:
C₈H₇ClO

[ 分子量 ]:
154.594

[ 闪点 ]:
89.6±11.0 °C

[ 精确质量 ]:
154.018539

[ PSA ]:
17.07000

[ LogP ]:
2.09

[ 外观性状 ]:
透明琥珀色液体

[ 蒸汽压 ]:
0.4±0.4 mmHg at 25°C

[ 折射率 ]:
1.532

[ 储存条件 ]:
库房低温通风干燥

邻氯苯乙酮MSDS

邻氯苯乙酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AM6310000

CHEMICAL NAME :: Acetophenone, 2'-chloro-

CAS REGISTRY NUMBER :: 2142-68-9

BEILSTEIN REFERENCE NO. :: 1858916

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H7-Cl-O

MOLECULAR WEIGHT :: 154.60

WISWESSER LINE NOTATION :: GR BV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CroHP# Personal Communication from H.P. Crocker, Ultimate Holding Co.-Reckitt & Colman Ltd., London, UK, Sept. 2, 1980 Volume(issue)/page/year: 02SEPT1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 880 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CroHP# Personal Communication from H.P. Crocker, Ultimate Holding Co.-Reckitt & Colman Ltd., London, UK, Sept. 2, 1980 Volume(issue)/page/year: 02SEPT1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7952 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

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邻氯苯乙酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39-S45-S36/37/39-S28A

[ 危险品运输编码 ]:
UN 3416 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
AM6310000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2914509090

邻氯苯乙酮合成路线

邻氯苯乙酮上下游产品

邻氯苯乙酮上游产品

邻氯苯乙酮下游产品

邻氯苯乙酮制备

1.邻硝基乙苯法。2.邻氯苯甲酰氯法向反应器中先加入二氯甲烷，其中悬浮固体无水三氯化铝。再加入烷基铝卤化物（CH3）1.5AlCl1.5。当二氯甲烷开始回流时，迅速加入邻氯苯甲酰氯，添加后，继续搅拌1h。然后将反应混合物注入水中。此时因放热引起分解反应而使二氯甲烷沸腾。经蒸馏处理得产品。邻氯苯甲酰氯用量0.3mol，（CH3）1.5AlCl1.5 0.21mol，三氯化铝用量0.1mol；对 1g 邻氯苯甲酰氯采用 1g -10g 二氯甲烷。反应温度约 40℃ ，产品收率98%。

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邻氯苯乙酮海关

[ 海关编码 ]: 2914700090

[ 中文概述 ]:
2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

邻氯苯乙酮文献

[Saccharomyces cerevisiae B5 efficiently and stereoselectively reduces 2'-chloroacetophenone to R-2'-chloro-1-phenylethanol in the presence of 5% ethanol].

Sheng Wu Gong Cheng Xue Bao 19(2) , 206-11, (2003)

(R)-chlorprenaline, a selective activator of beta2 receptor and an effective drug for bronchitis and asthma, is industrially prepared from (R)-2'-chloro-1-phenyl-ethanol. In this communication, we des...

Spectral differentiation and gas chromatographic/mass spectrometric analysis of the lacrimators 2-chloroacetophenone and o-chlorobenzylidene malononitrile.

J. Forensic Sci. 31(2) , 658-65, (1986)

2-Chloroacetophenone (CN) and o-chlorobenzylidene malononitrile (CS) are the most common chemical agents used as lacrimators in the United States. There is a lack of complete spectral data on these co...

Improving the enantioselective bioreduction of aromatic ketones mediated by Aspergillus terreus and Rhizopus oryzae: the role of glycerol as a co-solvent. Andrade LH, et al.

Tetrahedron Asymmetry 20(13) , 1521-25, (2009)

更多文献

邻氯苯乙酮

邻氯苯乙酮用途

邻氯苯乙酮名称

邻氯苯乙酮物理化学性质

邻氯苯乙酮MSDS

详细MSDS(安全技术说明书)

邻氯苯乙酮毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

邻氯苯乙酮安全信息

邻氯苯乙酮合成路线

详细合成路线

邻氯苯乙酮上下游产品

邻氯苯乙酮上游产品

邻氯苯乙酮下游产品

邻氯苯乙酮制备

邻氯苯乙酮海关

邻氯苯乙酮文献

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