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花椒素

花椒素用途

Xanthoxylin (Xanthoxyline) 是从 Zanthoxylum simulans 中分离出来的。 Xanthoxylin (Xanthoxyline) 具有抗真菌 (antifungal) 和抗癫痫作用。

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花椒素名称

[ CAS 号 ]:
90-24-4

[ 中文名 ]:
2-羟基-4,6-二甲氧基苯乙酮

[ 英文名 ]:
Xanthoxylin

[中文别名 ]:

[英文别名 ]:

2-HYDROXY-4,6-DIMETHOXYACETOPHENONE
MFCD00017243
Brevifolin (VAN)
EINECS 201-978-3
4,6-Dimethoxy-2-hydroxyacetophenone
Phloracetophenone 4,6-Dimethyl Ether
2,4-Dimethoxy-6-hydroxyacetophenone
Acetophenone, 2'-hydroxy-4',6'-dimethoxy-
Ethanone, 1-(2-hydroxy-4,6-dimethoxyphenyl)-
1-(2-Hydroxy-4,6-dimethoxyphenyl)ethanone

花椒素生物活性

[ 描述 ]:

Xanthoxylin (Xanthoxyline) 是从 Zanthoxylum simulans 中分离出来的。 Xanthoxylin (Xanthoxyline) 具有抗真菌 (antifungal) 和抗癫痫作用。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Cechinel Filho V, et al. Antispasmodic activity of xanthoxyline derivatives: structure-activity relationships.J Pharm Sci. 1995 Apr;84(4):473-5.

[2]. Pinheiro TR, et al. In vitro antifungal evaluation and studies on the mode of action of xanthoxyline derivatives.Arzneimittelforschung. 1999 Dec;49(12):1039-43.

花椒素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
355.1±37.0 °C at 760 mmHg

[ 熔点 ]:
80-84 °C(lit.)

[ 分子式 ]:
C₁₀H₁₂O₄

[ 分子量 ]:
196.200

[ 闪点 ]:
141.2±20.0 °C

[ 精确质量 ]:
196.073563

[ PSA ]:
55.76000

[ LogP ]:
2.37

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.528

[ 储存条件 ]:
室温

花椒素MSDS

花椒素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2914509090

花椒素合成路线

花椒素上下游产品

花椒素上游产品

花椒素下游产品

花椒素海关

[ 海关编码 ]: 2914509090

[ 中文概述 ]:
2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

花椒素文献

Collateral sensitivity of resistant MRP1-overexpressing cells to flavonoids and derivatives through GSH efflux.

Biochem. Pharmacol. 90(3) , 235-45, (2014)

The multidrug resistance protein 1 (MRP1) is involved in multidrug resistance of cancer cells by mediating drug efflux out of cells, often in co-transport with glutathione (GSH). GSH efflux mediated b...

Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice.

J. Pharmacol. Exp. Ther. 278(1) , 304-12, (1996)

The antinociceptive effect of the novel xanthoxyline derivative 2-(4-bromobenzoyl)-3-methyl-4-6-dimethoxy benzofuran) (BMDB), given i.p., p.o., s.c., subplantarly, intrathecally or by i.c.v. routes wa...

Synthesis of chalcone analogues with increased antileishmanial activity.

Bioorg. Med. Chem. 14(5) , 1538-45, (2006)

Eighteen analogues of an active natural chalcone were synthesized using xanthoxyline and some derivatives, and these analogues were tested for selective activity against both promastigotes and intrace...

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花椒素