< 生产厂家价格 >

氟达拉滨

氟达拉滨用途

Fludarabine(NSC 118218)是DNA合成抑制剂。

点击显示

氟达拉滨名称

[ CAS 号 ]:
21679-14-1

[ 中文名 ]:
氟达拉宾

[ 英文名 ]:
Fludarabine

[中文别名 ]:

[英文别名 ]:

UNII-P2K93U8740
9-b-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
9-β-D-Arabinofuranosyl-2-fluoroadenine
MFCD00132942
9H-Purin-6-amine, 9-β-D-arabinofuranosyl-2-fluoro-
Fludarabine des-phosphate
9-(β-D-Arabinofuranosyl)-2-fluoro-9H-purin-6-amine
9-b-D-Arabinofuranosyl-2-fluoroadenine
Fludarabine
EINECS 244-525-5

氟达拉滨生物活性

[ 描述 ]:

Fludarabine(NSC 118218)是DNA合成抑制剂。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 癌症

[参考文献]

[1]. Rai KR, et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med. 2000 Dec 14;343(24):1750-7.

[2]. Tournilhac O, et al. Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood. 2004 Jan 1;103(1):363-5. Epub 2003 Sep 11.

[相关活性小分子]

氟达拉滨物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 沸点 ]:
747.3±70.0 °C at 760 mmHg

[ 熔点 ]:
265-268ºC

[ 分子式 ]:
C₁₀H₁₂FN₅O₄

[ 分子量 ]:
285.232

[ 闪点 ]:
405.8±35.7 °C

[ 精确质量 ]:
285.087341

[ PSA ]:
139.54000

[ LogP ]:
-0.40

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±2.6 mmHg at 25°C

[ 折射率 ]:
1.876

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMF: 20 mg/mL, clear, faintly yellow

氟达拉滨MSDS

详细MSDS(安全技术说明书)

氟达拉滨毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU6207000

CHEMICAL NAME :: Adenine, 9-beta-D-arabinofuranosyl-2-fluoro-

CAS REGISTRY NUMBER :: 21679-14-1

LAST UPDATED :: 198909

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H12-F-N5-O4

MOLECULAR WEIGHT :: 285.27

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ GF IZ D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 100 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 210,291,1989

点击显示

氟达拉滨安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R23/24/25;R36/37/38;R39

[ 安全声明 (欧洲) ]:
S26-S36/37-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AU6207000

氟达拉滨制备

【方法一】
2，4，5，6-四氨基嘧啶和甲酰胺一起加热环合，得2，6-二氨基嘌呤。用乙酸酐-吡啶络合物酰化，得2，6-二乙酰胺基嘌呤。接着和2，3，5-三-O-苄基-D阿拉伯呋喃糖基氯化物反应，得化合物(I)。(I)脱乙酰化得化合物(Ⅱ)。(II)在氟硼酸-四氢呋喃中，先亚硝化，再取代，得化合物(IlI)。在三氯化硼作用下，脱去苄基得氟达拉滨。以2，3，5-三-O-苄基-D-阿拉伯呋喃糖基氯化物计，收率17.5%。

点击显示

氟达拉滨文献

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Drug Metab. Dispos. 36 , 1385-405, (2008)

We present herein a compilation and trend analysis of human i.v. pharmacokinetic data on 670 drugs representing, to our knowledge, the largest publicly available set of human clinical pharmacokinetic ...

更多文献

氟达拉滨

氟达拉滨用途

氟达拉滨名称

氟达拉滨生物活性

氟达拉滨物理化学性质

氟达拉滨MSDS

详细MSDS(安全技术说明书)

氟达拉滨毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

氟达拉滨安全信息

氟达拉滨制备

氟达拉滨文献

相关化工产品/化学物质：

相关药品：

推荐生产厂家/供应商：

相关化合物