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文多灵

文多灵用途

Vindoline 是一种从 Catharanthus roseus 叶片中提取的长春花生物碱,对微管蛋白 (tubulin) 的自组装具有弱抑制作用。

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文多灵名称

[ CAS 号 ]:
2182-14-1

[ 中文名 ]:
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[ 英文名 ]:
Vindoline

[中文别名 ]:

文朵灵

[英文别名 ]:

Vindoline
Vindoline (8CI)
vindolin
EINECS 218-558-0
Vindoline, (-)-

文多灵生物活性

[ 描述 ]:

Vindoline 是一种从 Catharanthus roseus 叶片中提取的长春花生物碱,对微管蛋白 (tubulin) 的自组装具有弱抑制作用。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白

信号通路 >> 细胞骨架 >> 微管/微管蛋白

[参考文献]

[1]. Prakash V, et al. Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline. Biochemistry. 1991 Jan 22;30(3):873-80.

文多灵物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
569.8±50.0 °C at 760 mmHg

[ 熔点 ]:
163-165ºC

[ 分子式 ]:
C₂₅H₃₂N₂O₆

[ 分子量 ]:
456.531

[ 闪点 ]:
298.4±30.1 °C

[ 精确质量 ]:
456.226044

[ PSA ]:
88.54000

[ LogP ]:
2.20

[ 外观性状 ]:
灰白色固体

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.626

[ 储存条件 ]:
-20°C

文多灵MSDS

文多灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CJ0120000

CHEMICAL NAME :: Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1- methyl-, methyl ester, (2-beta,3-beta,4-beta,5-alpha,12-beta,19-alpha)-

CAS REGISTRY NUMBER :: 2182-14-1

LAST UPDATED :: 198009

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C25-H32-N2-O6

MOLECULAR WEIGHT :: 456.59

WISWESSER LINE NOTATION :: T C6 B5665 2AB S BX IN QN NU JH&&TTTJ FO1 I1 KVO1 KQ LOV1 M2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement

REFERENCE :: 33GVAL "Catharanthus Alkaloids," Taylor, W.I., and N.R. Farnsworth, eds., New York, Marcel Dekker, 1975 Volume(issue)/page/year: -,73,1975

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文多灵安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H341

[ 警示性声明 ]:
P281

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
68

[ 安全声明 (欧洲) ]:
36/37-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CJ0120000

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文多灵文献

Increased availability of tryptophan in 5-methyltryptophan-tolerant shoots of Catharanthus roseus and their postharvest in vivo elicitation induces enhanced vindoline production.

Appl. Biochem. Biotechnol. 168(3) , 568-79, (2012)

Ten 5-methyltryprophan (5-MT)-resistant multiple shoot culture lines in three genotypes of Catharanthus roseus were selected in vitro. The variant shoot lines displayed a differential threshold tolera...

Simultaneous determination of vinblastine and its monomeric precursors vindoline and catharanthine in Catharanthus roseus by capillary electrophoresis-mass spectrometry.

J. Sep. Sci. 34 , 2885-2892, (2011)

Catharanthus roseus is an important dicotyledonous medicinal plant that contains various anticancer components, such as vinblastine (VLB) and its monomeric precursors (vindoline and catharanthine). A ...

Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues.

Bioorg. Med. Chem. Lett. 20(22) , 6408-10, (2010)

The examination of the catharanthine C16 substituent effects on the Fe(III)-promoted biomimetic coupling reaction with vindoline is detailed, confirming the importance of the presence of a C16 electro...

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