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苏达灭

苏达灭用途

6-Hydroxymelatonin 是褪黑素 (Melatonin) 通过 CYP1A2 代谢的主要代谢物。

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苏达灭名称

[ CAS 号 ]:
2208-41-5

[ 中文名 ]:
苏达灭

[ 英文名 ]:
6-Hydroxymelatonin

[中文别名 ]:

[英文别名 ]:

6-HydroxyMelatonin
6-Hydroxy Melatonin

苏达灭生物活性

[ 描述 ]:

6-Hydroxymelatonin 是褪黑素 (Melatonin) 通过 CYP1A2 代谢的主要代谢物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Härtter S, et al. Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study. Clin Pharmacol Ther. 2001 Jul;70(1):10-6.

[相关活性小分子]

苏达灭物理化学性质

[ 密度 ]:
1.266g/cm3

[ 沸点 ]:
564.7ºC at 760mmHg

[ 熔点 ]:
172-175ºC

[ 分子式 ]:
C₁₃H₁₆N₂O₃

[ 分子量 ]:
248.27800

[ 闪点 ]:
295.3ºC

[ 精确质量 ]:
248.11600

[ PSA ]:
74.35000

[ LogP ]:
1.95160

[ 蒸汽压 ]:
2.35E-13mmHg at 25°C

[ 折射率 ]:
1.627

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
alcohol: soluble

苏达灭毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC3607000

CHEMICAL NAME :: Acetamide, N-(2-(6-hydroxy-5-methoxyindol-3-yl)ethyl)-

CAS REGISTRY NUMBER :: 2208-41-5

BEILSTEIN REFERENCE NO. :: 0483231

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H16-N2-O3

MOLECULAR WEIGHT :: 248.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8 mg/kg

SEX/DURATION :: male 20 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 33,618,1985

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苏达灭安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H351

[ 警示性声明 ]:
P281

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22-40

[ 安全声明 (欧洲) ]:
36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AC3607000

[ 海关编码 ]:
2933990090

苏达灭合成路线

详细合成路线

苏达灭制备

在叔胺存在下，乙硫醇与光气作用制得乙硫基甲酰氯，再与二异丁胺作用合成丁草特。

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苏达灭海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

苏达灭文献

Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro.

Mol. Cell. Endocrinol. 404 , 1-8, (2015)

Melatonin and its metabolites including 6-hydroxymelatonin (6(OH)M), N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) and 5-methoxytryptamine (5MT) are endogenously produced in human epidermis. This...

Predominance of 2-hydroxymelatonin over melatonin in plants.

J. Pineal Res. 59 , 448-54, (2015)

The cloning of the gene encoding melatonin 2-hydroxylase (M2H), which is responsible for the synthesis of 2-hydroxymelatonin, has expanded the study of melatonin metabolism in plants. Kinetic analysis...

Molecular cloning of melatonin 2-hydroxylase responsible for 2-hydroxymelatonin production in rice (Oryza sativa).

J. Pineal Res. 58(3) , 343-51, (2015)

Although melatonin biosynthetic genes from plants have been cloned, the melatonin catabolism mechanisms remain unclear. To clone the genes responsible for melatonin metabolism, we ectopically expresse...

更多文献

苏达灭

苏达灭用途

苏达灭名称

苏达灭生物活性

苏达灭物理化学性质

苏达灭毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

苏达灭安全信息

苏达灭合成路线

详细合成路线

苏达灭制备

苏达灭海关

苏达灭文献

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