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曲磷胺

曲磷胺用途

Trofosfamide 是一种有口服生物活性的氧氮磷环类衍生物,具有抗癌活性。

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曲磷胺名称

[ CAS 号 ]:
22089-22-1

[ 中文名 ]:
曲磷胺

[ 英文名 ]:
Trofosfamide

[英文别名 ]:

Asta Z 4828
A-4828
TROPHOSPHAMIDE
Trofosfamide
ifosfamide mustard
Trilophosphamide
triphosphamide

曲磷胺生物活性

[ 描述 ]:

Trofosfamide 是一种有口服生物活性的氧氮磷环类衍生物,具有抗癌活性。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Witte HM, et al. Trofosfamide in the treatment of elderly or frail patients with diffuse large B-cell lymphoma. J Cancer Res Clin Oncol. 2019 Jan;145(1):129-136.

[2]. Görn M, et al. A pilot study of docetaxel and trofosfamide as second-line 'metronomic' chemotherapy in the treatment of metastatic non-small cell lung cancer (NSCLC). Onkologie. 2008 Apr;31(4):185-9.

曲磷胺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
393.7±52.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₁₈Cl₃N₂O₂P

[ 分子量 ]:
323.584

[ 闪点 ]:
191.9±30.7 °C

[ 精确质量 ]:
322.017151

[ PSA ]:
42.59000

[ LogP ]:
1.77

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.519

曲磷胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RP5880000

CHEMICAL NAME :: 2H-1,3,2-Oxazaphosphorine, 2-(bis(2-chloroethyl)amino)-3-(2-chloroethyl)tetrahyd ro-, 2-oxide

CAS REGISTRY NUMBER :: 22089-22-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: C9-H18-Cl3-N2-O2-P

MOLECULAR WEIGHT :: 323.61

WISWESSER LINE NOTATION :: T6NTJ A1 DOV1- ET5OVXTJ ER& C-& AL6XTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria Blood - leukopenia Blood - thrombocytopenia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 202 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 464 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 212 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 157 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Dominant lethal test

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Heritable translocation test

MUTATION DATA

TEST SYSTEM :: Rodent - hamster

DOSE/DURATION :: 3300 ug/kg

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 38,35,1977

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曲磷胺安全信息

[ 海关编码 ]:
2934999090

曲磷胺上下游产品

曲磷胺上游产品

曲磷胺下游产品

曲磷胺海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

曲磷胺