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五氯柳胺

五氯柳胺用途

Oxyclozanide 是一种水杨酰苯胺驱虫药,主要通过解偶联吸虫中的氧化磷酸化发挥作用。

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五氯柳胺名称

[ CAS 号 ]:
2277-92-1

[ 中文名 ]:
氯羟柳胺

[ 英文名 ]:
Oxyclozanide

[中文别名 ]:

五氯柳胺

[英文别名 ]:

MFCD00864507
Zanilox
Oxyclozanide
diplin
3,3',5,5',6-Pentachloro-2'-hydroxysalicylanilid
EINECS 218-904-0
OXYCLOZAMIDE
Oxycloxanide
zanil
Saucylanilide

五氯柳胺生物活性

[ 描述 ]:

Oxyclozanide 是一种水杨酰苯胺驱虫药,主要通过解偶联吸虫中的氧化磷酸化发挥作用。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[ 靶点 ]

Parasite[1]

[参考文献]

[1]. Gokbulut C, et al. Comparative pharmacokinetics of levamisole-oxyclozanide combination in sheep and goats following per os administration. Can J Vet Res. 2014 Oct;78(4):316-20.

[相关活性小分子]

五氯柳胺物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
446.0±45.0 °C at 760 mmHg

[ 熔点 ]:
205 - 210ºC

[ 分子式 ]:
C₁₃H₆Cl₅NO₃

[ 分子量 ]:
401.457

[ 闪点 ]:
223.5±28.7 °C

[ 精确质量 ]:
398.879028

[ PSA ]:
69.56000

[ LogP ]:
8.67

[ 外观性状 ]:
白色至淡黄色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.722

[ 储存条件 ]:
0-6°C

五氯柳胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV8576000

CHEMICAL NAME :: Benzanilide, 2,2'-dihydroxy-3,3',5,5',6-pentachloro-

CAS REGISTRY NUMBER :: 2277-92-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H6-Cl5-N-O3

MOLECULAR WEIGHT :: 401.45

WISWESSER LINE NOTATION :: QR BG DG FMVR BQ CG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 210,744,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: VETRAX Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888- Volume(issue)/page/year: 78,267,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: VETRAX Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888- Volume(issue)/page/year: 78,267,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETRAX Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888- Volume(issue)/page/year: 78,267,1966

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五氯柳胺安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R22;R50/53

[ 安全声明 (欧洲) ]:
S60-S61

[ 危险品运输编码 ]:
UN 3077

[ RTECS号 ]:
CV8576000

[ 海关编码 ]:
2924299090

五氯柳胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

五氯柳胺文献

[The investigation of short term efficiency of oxfendazole + oxyclozanide paste and tablet formulations against gastrointestinal nematodes in sheep].

Turkiye. Parazitol. Derg. 32(2) , 134-8, (2008)

The aim of this study was to investigate the effectiveness of tablet and paste formulations of Oxfendazole and Oxyclozanide combinations against subclinical gastrointestinal nematode infections and to...

Determination of bithionol, bromophen, nitroxynil, oxyclozanide, and tribromsalan in milk with liquid chromatography coupled with tandem mass spectrometry.

J. AOAC Int. 93(4) , 1340-6, (2010)

LC/MS/MS was developed to determine the residues of bithionol (BTN), bromofen (BMF), nitroxynil (NTX), oxyclozanide (OCZ), and tribromsalan (TBS) in milk. Samples were extracted with ethyl acetate and...

Immunological detection of chemotherapeutic success in bovine fasciolosis using the specific antigen f2.

Vet. Parasitol. 45(1-2) , 81-8, (1992)

An improved hemagglutination (HA) test using the purified specific f2 antigen of Fasciola hepatica has been evaluated with regard to its potential use for the prediction of chemotherapeutic success in...

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