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夫马洁林

夫马洁林用途

Fumagillin(NSC9168)由烟曲霉菌中提取,有抗抗阿米巴活性。

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夫马洁林名称

[ CAS 号 ]:
23110-15-8

[ 中文名 ]:
烟曲霉素

[ 英文名 ]:
fumagillin

[中文别名 ]:

[英文别名 ]:

FUGILLIN
FUMADIL B
amebacillin
fumagillin
EINECS 245-433-8
MFCD03990453
fumidil
h-3
FUMIDIL B
AMEBACILIN

夫马洁林生物活性

[ 描述 ]:

Fumagillin(NSC9168)由烟曲霉菌中提取,有抗抗阿米巴活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Lefkove, B., B. Govindarajan, and J.L. Arbiser, Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors. Expert Rev Anti Infect Ther, 2007. 5(4): p. 573-9.

[相关活性小分子]

夫马洁林物理化学性质

[ 密度 ]:
1.19g/cm3

[ 沸点 ]:
608.8ºC at 760mmHg

[ 熔点 ]:
>190ºC-192ºC

[ 分子式 ]:
C₂₆H₃₄O₇

[ 分子量 ]:
458.54400

[ 闪点 ]:
198.8ºC

[ 精确质量 ]:
458.23000

[ PSA ]:
97.89000

[ LogP ]:
3.91540

[ 外观性状 ]:
淡黄色固体

[ 蒸汽压 ]:
2.7E-16mmHg at 25°C

[ 折射率 ]:
1.562

[ 储存条件 ]:
-20°C，充氩储存

夫马洁林MSDS

详细MSDS(安全技术说明书)

夫马洁林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HE1750000

CHEMICAL NAME :: 2,4,6,8-Decatetraenedioic acid, 4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1- oxaspiro(2,5)oct-6-yl ester

CAS REGISTRY NUMBER :: 23110-15-8

LAST UPDATED :: 199309

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C26-H34-O7

MOLECULAR WEIGHT :: 458.60

WISWESSER LINE NOTATION :: BT3OTJ B C2UY

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1834,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 1,54,1951 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 25 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: 85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H., Paris, Masson et Cie, 1971 Volume(issue)/page/year: -,95,1971

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夫马洁林安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H312-H319-H332

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
UN 1648 3 / PGII

[ WGK德国 ]:
3

[ RTECS号 ]:
HE1750000

[ 海关编码 ]:
29419090

夫马洁林制备

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夫马洁林文献

Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide.

ACS Nano 8(7) , 7305-17, (2014)

Antiangiogenesis has been extensively explored for the treatment of a variety of cancers and certain inflammatory processes. Fumagillin, a mycotoxin produced by Aspergillus fumigatus that binds methio...

Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.

PLoS ONE 7(4) , e35388, (2012)

Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central...

The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes.

Microbiology 157(Pt 5) , 1481-8, (2011)

Larvae of Galleria mellonella are widely used to evaluate microbial virulence and to assess the in vivo efficacy of antimicrobial agents. The aim of this work was to examine the ability of an Aspergil...

更多文献

夫马洁林

夫马洁林用途

夫马洁林名称

夫马洁林生物活性

夫马洁林物理化学性质

夫马洁林MSDS

详细MSDS(安全技术说明书)

夫马洁林毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

夫马洁林安全信息

夫马洁林制备

夫马洁林文献

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