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对甲苯磺酸3-丁炔酯

对甲苯磺酸3-丁炔酯用途

Propargyl-Tos 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

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对甲苯磺酸3-丁炔酯名称

[ CAS 号 ]:
23418-85-1

[ 中文名 ]:
对甲苯磺酸 3-丁炔酯

[ 英文名 ]:
Propargyl-Tos

[中文别名 ]:

[英文别名 ]:

3-Butyn-1-ol, 4-methylbenzenesulfonate
p-Toluenesulfonic Acid 3-Butynyl Ester
homopropargyl alcohol tosylate
4-tosyloxy-1-butyne
3-butynyl p-tosylate
but-3-yn-1-yl tosylate
3-Butyn-1-yl 4-methylbenzenesulfonate
3-Butynyl Tosylate
but-3-yn-1-yl p-toluenesulfonate
3-(1-Butynyl)-4-toluenesulphonate

对甲苯磺酸3-丁炔酯生物活性

[ 描述 ]:

Propargyl-Tos 是一种可降解 (cleavable) 的 ADC linker,可用于合成抗体偶联药物 (ADC)。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 抗体- 药物偶联物 >> ADC连接器

[ 靶点 ]

Cleavable

[体外研究]

ADC由抗体组成,抗体通过ADC连接体连接ADC细胞毒素[1]。

[参考文献]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

对甲苯磺酸3-丁炔酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
352.0±25.0 °C at 760 mmHg

[ 分子式 ]:
C₁₁H₁₂O₃S

[ 分子量 ]:
224.276

[ 闪点 ]:
166.7±23.2 °C

[ 精确质量 ]:
224.050720

[ PSA ]:
51.75000

[ LogP ]:
2.01

[ 外观性状 ]:
液体;Light yellow to Brown clear liquid

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.535

[ 储存条件 ]:
Refrigerator (+4°C)

对甲苯磺酸3-丁炔酯MSDS

对甲苯磺酸3-丁炔酯安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2905290000

对甲苯磺酸3-丁炔酯合成路线

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对甲苯磺酸3-丁炔酯制备

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对甲苯磺酸3-丁炔酯海关

[ 海关编码 ]: 2905290000

[ 中文概述 ]:
2905290000 其他不饱和一元醇。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2905290000 unsaturated monohydric alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

对甲苯磺酸3-丁炔酯文献

Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.

J. Med. Chem. 39(16) , 3179-87, (1996)

A novel series of aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines with dopaminergic activity is described. The structure-activity relationships of this series were studied by synthesis of analo...

A new class of histamine H(3)-receptor antagonists: synthesis and structure-activity relationships of 7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolines.

Bioorg. Med. Chem. Lett. 13(13) , 2131-5, (2003)

The synthesis and biological evaluation of novel cycloheptaquinoline antagonists of the human H(3) receptor are described. Two series of compounds, bearing either an amino substituent or an alkyne lin...

Synthesis of Antitumor Lycorines by Intramolecular Diels-Alder Reaction.

J. Org. Chem. 61(5) , 1650-1654, (1996)

Pharmacologically interesting lycorines were obtained by a short, efficient method based on an intramolecular Diels-Alder reaction between an alpha-pyrone and an alkyne, followed by loss of CO(2) in a...

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