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7-甲基香豆素

7-甲基香豆素用途

7-甲基香豆素是一种香豆素,具有很强的保肝活性和抗氧化作用[1]。

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7-甲基香豆素名称

[ CAS 号 ]:
2445-83-2

[ 中文名 ]:
7-甲基香豆素

[ 英文名 ]:
7-Methylcoumarin

[英文别名 ]:

Coumarin, 7-methyl-
7-methyl-coumarin
2H-1-Benzopyran-2-one, 7-methyl-
7-Methyl-2H-1-benzopyran-2-one
7-Methyl-2H-chromen-2-one
2H-1-Benzopyran-2-one,7-methyl
7-Methylcoumarin
EINECS 219-499-3
7-Methyl-cumarin
COUMARIN,7-METHYL

7-甲基香豆素生物活性

[ 描述 ]:

7-甲基香豆素是一种香豆素,具有很强的保肝活性和抗氧化作用[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Sancheti S, et, al. Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats. Drug Chem Toxicol. 2013 Jan;36(1):42-7.

7-甲基香豆素物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
313.1±0.0 °C at 760 mmHg

[ 熔点 ]:
128-130 °C(lit.)

[ 分子式 ]:
C₁₀H₈O₂

[ 分子量 ]:
160.17

[ 闪点 ]:
125.9±19.5 °C

[ 精确质量 ]:
160.052429

[ PSA ]:
30.21000

[ LogP ]:
1.85

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.583

[ 储存条件 ]:
室温，干燥

7-甲基香豆素MSDS

7-甲基香豆素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN7792100

CHEMICAL NAME :: Coumarin, 7-methyl-

CAS REGISTRY NUMBER :: 2445-83-2

BEILSTEIN REFERENCE NO. :: 0122625

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H8-O2

MOLECULAR WEIGHT :: 160.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 258 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 76,186,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,747,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7980 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

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7-甲基香豆素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
23/24/25

[ 安全声明 (欧洲) ]:
S1-S13-S45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
GN7792100

[ 海关编码 ]:
2932209090

7-甲基香豆素合成路线

7-甲基香豆素上下游产品

7-甲基香豆素上游产品

7-甲基香豆素下游产品

7-甲基香豆素海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-甲基香豆素文献

Simultaneous determination of byak-angelicin and oxypeucedanin hydrate in rat plasma by column-switching high-performance liquid chromatography with ultraviolet detection.

J. Chromatogr. B. Biomed. Sci. Appl. 753(2) , 309-14, (2001)

A simple and sensitive column-switching HPLC method was developed for the simultaneous determination of two furocoumarin compounds, byak-angelicin and oxypeucedanin hydrate, which are the main compone...

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes.

Xenobiotica 46 , 14-24, (2016)

1. Information about the metabolism of compounds is essential in drug discovery and development, risk assessment of chemicals and further development of predictive methods. 2. In vitro and in silico m...

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