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4-甲基水杨酸

4-甲基水杨酸用途

4-甲基水杨酸是一种水杨酸。4-甲基水杨酸衍生物是一种选择性组织非特异性碱性磷酸酶(TNAP)和肠碱性磷酸酶抑制剂[1]。

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4-甲基水杨酸名称

[ CAS 号 ]:
50-85-1

[ 中文名 ]:
4-甲基水杨酸

[ 英文名 ]:
2-Hydroxy-4-methylbenzoic acid

[中文别名 ]:

[英文别名 ]:

2-Hydroxy-4-methylbenzoic acid,m-Cresotic acid
4-Methylsalicylic acid
2-Hydroxy-4-methyl-benzoic acid
EINECS 200-068-3
2-Hydroxy-p-toluic Acid
Benzoic acid, 2-hydroxy-4-methyl-
m-Cresotic acid
2-Hydroxy-4-methylbenzoic acid
MFCD00002454

4-甲基水杨酸生物活性

[ 描述 ]:

4-甲基水杨酸是一种水杨酸。4-甲基水杨酸衍生物是一种选择性组织非特异性碱性磷酸酶(TNAP)和肠碱性磷酸酶抑制剂[1]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> IAP

研究领域 >> 炎症/免疫

[参考文献]

[1]. Mumtaz A, et al. Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies. Bioorg Chem. 2020 Aug;101:103996.

4-甲基水杨酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
315.2±30.0 °C at 760 mmHg

[ 熔点 ]:
173-177 °C(lit.)

[ 分子式 ]:
C₈H₈O₃

[ 分子量 ]:
152.147

[ 闪点 ]:
158.6±21.1 °C

[ 精确质量 ]:
152.047348

[ PSA ]:
57.53000

[ LogP ]:
2.52

[ 外观性状 ]:
黄褐色

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.600

[ 储存条件 ]:
室温

4-甲基水杨酸MSDS

4-甲基水杨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GP3920100

CHEMICAL NAME :: 2,4-Cresotic acid

CAS REGISTRY NUMBER :: 50-85-1

BEILSTEIN REFERENCE NO. :: 2208140

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QVR BQ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 7,289,1970

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4-甲基水杨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GP3920100

[ 海关编码 ]:
2918219000

4-甲基水杨酸合成路线

4-甲基水杨酸上下游产品

4-甲基水杨酸上游产品

4-甲基水杨酸下游产品

4-甲基水杨酸海关

[ 海关编码 ]: 2918290000

[ 中文概述 ]:
2918290000 其他含酚基但不含其他含氧基羧酸及其酸酐、酰卤化物、过氧化物和过氧酸及它们的衍生物。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

4-甲基水杨酸文献

[New highly phosphorescent heteroleptic tris-cyclometalated iridium (III) complexes: synthesis and photophysical characterization].

Guang Pu Xue Yu Guang Pu Fen Xi 30(1) , 170-3, (2010)

New heteroleptic tris-cyclometalated iridium(III) complexes (ppy)2 Ir(LX) (ppy==2-phenylpyridine, LX==Sal (salicylic acid), Msal (4-methylsalicylic acid), FSal(4-trifluoro methyl salicylic acid)) was ...

Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids.

Biochem. Pharmacol. 52 , 1643-1646, (1996)

Molecular characteristics of carboxylic acids were investigated for the ability to inhibit a purified medium chain acyl-CoA synthetase, using hexanoic acid as a substrate. Salicylic acid, 4-methylsali...

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