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2,2,6,6-四甲基哌啶-1-氧自由基

2,2,6,6-四甲基哌啶-1-氧自由基用途

Tempo 是一种经典的一氧化氮自由基,也是一种线粒体 ROS 的选择性清除剂,可在催化循环中使超氧化物歧化。Tempo 可诱导 DNA 链断裂,并可用作将伯醇氧化为醛的有机催化剂。Tempo 具有诱变和抗氧化作用。

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2,2,6,6-四甲基哌啶-1-氧自由基名称

[ CAS 号 ]:
2564-83-2

[ 中文名 ]:
2,2,6,6-四甲基哌啶氧化物

[ 英文名 ]:
2,2,6,6-Tetramethylpiperidinooxy

[中文别名 ]:

[英文别名 ]:

Tanan
2,6,6-Tetramethylpiperidine N-oxide
2,2,6,6-Tetramethyl piperidine-N-oxyl
(2,2,6,6-Tetramethyl-1-piperidinyl)oxidanyl
2,2,6,6-tetramethyl-1-piperidinyloxy radical
2,2,6,6-Tetramethylpiperidoxyl
free radical,2,2,6,6-Tetramethylpiperidine 1-oxyl
2,2,6,6-Tetramethyl-1-piperidinyloxy
2,2,6,6-Tetramethylpiperidine 1-Oxyl Free Radical
1-Piperidinyloxy, 2,2,6,6-tetramethyl-

2,2,6,6-四甲基哌啶-1-氧自由基生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

信号通路 >> 蛋白酪氨酸激酶 >> ROS

[参考文献]

[1]. Du K, et al. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773.

[2]. Guo X, et al. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225.

[3]. Lv H, et al. TEMPO catalyzed oxidative dehydrogenation of hydrazobenzenes to azobenzenes. Org Biomol Chem. 2020 Apr 22.

[4]. Chen X, et al. Isocitrate dehydrogenase 2 contributes to radiation resistance of oesophageal squamous cell carcinoma via regulating mitochondrial function and ROS/pAKT signalling. Br J Cancer. 2020 May 5.

2,2,6,6-四甲基哌啶-1-氧自由基物理化学性质

[ 密度 ]:
1 g/cm3

[ 沸点 ]:
193°C

[ 熔点 ]:
36-38 °C(lit.)

[ 分子式 ]:
C₁₀H₂₁NO?

[ 分子量 ]:
156.245

[ 闪点 ]:
154 °F

[ 精确质量 ]:
156.138840

[ PSA ]:
3.24000

[ LogP ]:
2.31290

[ 外观性状 ]:
橙色晶体或粉末

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Incompatible with strong acids, strong oxidizing agents. Refrigerate.

[ 水溶解性 ]:
可溶于：甲醇

2,2,6,6-四甲基哌啶-1-氧自由基MSDS

2,2,6,6-四甲基哌啶-1-氧自由基毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN8991900

CHEMICAL NAME :: Piperidinooxy, 2,2,6,6-tetramethyl-

CAS REGISTRY NUMBER :: 2564-83-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H18-N-O

MOLECULAR WEIGHT :: 156.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4500 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown. Volume(issue)/page/year: 8EHQ-0786-0607S

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2,2,6,6-四甲基哌啶-1-氧自由基安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C:Corrosive; Xi:Irritant

[ 风险声明 (欧洲) ]:
R34;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S24/25

[ 危险品运输编码 ]:
UN 3263 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
TN8991900

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29333999

2,2,6,6-四甲基哌啶-1-氧自由基合成路线

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2,2,6,6-四甲基哌啶-1-氧自由基海关

[ 海关编码 ]: 29333999

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