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头孢唑林

头孢唑林用途

Cefazolin 是第一代头孢类抗生素, 用于多种细菌感染的研究。

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头孢唑林名称

[ CAS 号 ]:
25953-19-9

[ 中文名 ]:
头孢唑啉

[ 英文名 ]:
Cefazolin

[中文别名 ]:

[英文别名 ]:

Cephazolin
Cephamezine
Cefazolinum
Cefazolina
Cephazoline
Cefazoline
Cephazolidin
Ancef
MFCD00243010
EINECS 247-362-8

头孢唑林生物活性

[ 描述 ]:

Cefazolin 是第一代头孢类抗生素, 用于多种细菌感染的研究。

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Antibiotic[1]

[体外研究]

头孢唑林(50-300μg/mL；6或24小时)对LPS(1μg/mL)刺激的C8-B4细胞有直接抗炎作用[1]。细胞活力测定[1]细胞系：小鼠C8-B4小胶质细胞浓度：50、100、150、200、250和300μg/mL孵育时间：6或24小时结果：抑制促炎细胞因子的产生。在50和100μg/mL时抑制IL-6的产生。

[体内研究]

头孢唑林(300mg/kg,术前1h腹腔注射,术后每日1次,连续5d)可减轻术后记忆和学习障碍。单用头孢唑林可导致小鼠认知功能障碍,可能是由于未经手术的小鼠出现短暂的肠道失调[1]。动物模型：6～8周龄CD-1雄性小鼠(体重31～36g)[1]剂量：300～500mg/kg给药：10mg/0.1ml,术前30min腹腔注射,每日1次,共5天。结果：术后小鼠学习记忆能力提高,非手术组小鼠学习记忆能力下降。

[参考文献]

[1]. Peng Liang, et al. Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice. J Neuroinflammation. 2018 Aug 22;15(1):235.

头孢唑林物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 熔点 ]:
198-200ºC

[ 分子式 ]:
C₁₄H₁₄N₈O₄S₃

[ 分子量 ]:
454.507

[ 精确质量 ]:
454.029999

[ PSA ]:
234.93000

[ LogP ]:
1.13

[ 外观性状 ]:
针状

[ 折射率 ]:
1.961

[ 储存条件 ]:
室温

头孢唑林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI0389900

CHEMICAL NAME :: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((5-methyl-1,3,4-thiadiazol-2-yl) thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-

CAS REGISTRY NUMBER :: 25953-19-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C14-H14-N8-O4-S3

MOLECULAR WEIGHT :: 454.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BYYADW Byoin Yakugaku. Hospital Pharmacology. (Yakuji Nippon Sha, 1-11 Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1975- Volume(issue)/page/year: 3,220,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BYYADW Byoin Yakugaku. Hospital Pharmacology. (Yakuji Nippon Sha, 1-11 Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1975- Volume(issue)/page/year: 3,220,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 164 gm/kg/26W-I

TOXIC EFFECTS :: Blood - normocytic anemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 7),1089,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 44100 mg/kg/35D-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Related to Chronic Data - death

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 28(Suppl 7),1007,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 11200 mg/kg/28D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: BYYADW Byoin Yakugaku. Hospital Pharmacology. (Yakuji Nippon Sha, 1-11 Izumi-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1975- Volume(issue)/page/year: 3,220,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1317 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 528 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1317 No. of Facilities: 318 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 16111 (estimated) No. of Female Employees: 13596 (estimated)

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头孢唑林安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
3004909090

头孢唑林合成路线

详细合成路线

头孢唑林上下游产品

头孢唑林上游产品

头孢唑林下游产品

头孢唑林制备

【方法一】
以头孢菌素C为原料制得。

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头孢唑林海关

[ 海关编码 ]: 3004909090

头孢唑林文献

Isolation of Escherichia coli strains with AcrAB-TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol and aminopenicillin from dogs admitted to a university veterinary hospital.

J. Vet. Med. Sci. 76(7) , 937-45, (2014)

Understanding the prevalence of antimicrobial-resistance and the relationship between emergence of resistant bacteria and clinical treatment can facilitate design of effective treatment strategies. We...

Aspiration sclerotherapy combined with pasireotide to improve reduction of large symptomatic hepatic cysts (SCLEROCYST): study protocol for a randomized controlled trial.

Trials 16 , 82, (2015)

Aspiration sclerotherapy is an effective therapeutic option for large symptomatic hepatic cysts. However, incomplete cyst reduction following aspiration sclerotherapy is frequently reported. Strong po...

Skeletal muscle and plasma concentrations of cefazolin during cardiac surgery in infants.

J. Thorac. Cardiovasc. Surg. 148(6) , 2634-41, (2014)

To describe the pharmacokinetics and tissue disposition of prophylactic cefazolin into skeletal muscle in a pediatric population undergoing cardiac surgery.The subjects included 12 children, with a me...

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头孢唑林

头孢唑林用途

头孢唑林名称

头孢唑林生物活性

头孢唑林物理化学性质

头孢唑林毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

头孢唑林安全信息

头孢唑林合成路线

详细合成路线

头孢唑林上下游产品

头孢唑林上游产品

头孢唑林下游产品

头孢唑林制备

头孢唑林海关

头孢唑林文献

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