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聚半乳糖醛酸

聚半乳糖醛酸用途

聚半乳糖醛酸(半乳糖醛酸聚合物)是透明胶体,是细胞壁的主要成分。聚半乳糖醛酸可用于制备银纳米粒子(AgNP),作为一种抗氧化剂和抗炎药,可保护细胞免受活性氧升高的破坏作用,并加速伤口愈合。聚半乳糖醛酸纳米粒也显示出抗菌活性[1][2]。

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聚半乳糖醛酸名称

[ CAS 号 ]:
25990-10-7

[ 中文名 ]:
果胶酸

[ 英文名 ]:
Polygalacturonic acid

[英文别名 ]:

DL-Galacturonic acid
α-D-Galacturonic acid
MFCD00131972
D-Galacturonic acid (9CI)
D-Galacturonic acid
δ-Galacturonic acid

聚半乳糖醛酸生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

聚半乳糖醛酸可用于形成持久的水凝胶,以延长药物的作用。例如,聚半乳糖醛酸水凝胶/透明质酸,结合布洛芬(HY-78131),可以防止硬膜外纤维化,防止椎板切除术雄性成年大鼠严重的瘢痕组织粘连,提高局部炎症控制的效率,并减少布洛芬的副作用[1]。聚半乳糖醛酸水凝胶/透明质酸(PGA-HA)(2%,200μL；24小时)对L929成纤维细胞的细胞毒性较低[1]。聚半乳糖醛酸(PGA)制备的(Ag-PGA/HA)-PVA纳米粒对革兰氏阳性菌具有抗菌活性；枯草芽孢杆菌和金黄色葡萄球菌,以及革兰氏阴性菌株；大肠杆菌[2]。

[体内研究]

聚半乳糖醛酸(外用；14天)可促进白化大鼠伤口感染的快速愈合[2]。动物模型：白化大鼠全层创伤模型(60天龄,180克)[2]剂量：银聚半乳糖醛酸/透明质酸纳米粒给药：应用于背肌筋膜；每天用酒精清洗伤口；结果：早期均未出现脓肿形成或增生性瘢痕；第5天或最后阶段；分别是第14天。从第8天开始,用(Ag-PGA/HA)-PVA纳米纤维和空白(PGA/HA)-PVC纳米纤维治疗,并在第14天诱导上皮化,伤口愈合显著。

[参考文献]

[1]. Lin CY, et al. Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. J Biomater Appl. 2016 May;30(10):1589-600.

[2]. El-Aassar MR, et al. Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies. Carbohydr Polym. 2020 Jun 15;238:116175.

聚半乳糖醛酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
553.4±50.0 °C at 760 mmHg

[ 分子式 ]:
C₆H₁₀O₇

[ 分子量 ]:
194.139

[ 闪点 ]:
302.6±26.6 °C

[ 精确质量 ]:
194.042648

[ LogP ]:
-1.49

[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C

[ 折射率 ]:
1.592

[ 储存条件 ]:
室温，密封

聚半乳糖醛酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

聚半乳糖醛酸文献

Leaf-cutting ant fungi produce cell wall degrading pectinase complexes reminiscent of phytopathogenic fungi.

BMC Biol. 8 , 156, (2010)

Leaf-cutting (attine) ants use their own fecal material to manure fungus gardens, which consist of leaf material overgrown by hyphal threads of the basidiomycete fungus Leucocoprinus gongylophorus tha...

A colorimetric method to quantify endo-polygalacturonase activity.

Enzyme Microb. Technol. 48 , 123-128, (2011)

We report a new colorimetric assay to quantify endo-polygalacturonase activity, which hydrolyzes polygalacturonic acid to produce smaller chains of galacturonate. Some of the reported polygalacturonas...

Polygalacturonase Isozymes Produced by Phomopsis cucurbitae in Relation to Postharvest Decay of Cantaloupe Fruit.

Phytopathology 87 , 1020-1025, (1997)

ABSTRACT Production of polygalacturonase (PG), a cell wall-degrading enzyme, by Phomopsis cucurbitae (latent infection fungus) was studied in relation to different carbon sources and various stages of...

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