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一水西沙必利

一水西沙必利用途

Cisapride是直接的、选择性5-HT4 receptor激动剂，IC50为0.483 μM。也是间接的拟副交感神经药。

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一水西沙必利名称

[ CAS 号 ]:
260779-88-2

[ 中文名 ]:
一水西沙必利

[ 英文名 ]:
CISAPRIDEMONOHYDRATE

[英文别名 ]:

CISAPRIDE MONOHYDRATE
UNII:VZV0A4I38W
VZV0A4I38W

一水西沙必利生物活性

[ 描述 ]:

一水西沙必利是一种口服有效的5-HT4受体激动剂和hERG抑制剂。一水西沙必利是一种促动力剂,可促进或恢复整个胃肠道的运动。一水西沙必利通过一种间接机制刺激胃肠运动活动,该机制涉及由肠肌间神经丛中的节后神经末梢介导的乙酰胆碱释放[1][2]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[ 靶点 ]

5-HT4 Receptor:0.14 μM (EC50)

[参考文献]

[1]. Wiseman, L.R., Faulds, D. Cisapride. Drugs 47, 116–152 (1994).

[2]. Toga T, et al. The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities. J Pharmacol Sci. 2007 Oct;105(2):207-10.

一水西沙必利物理化学性质

[ 分子式 ]:
C₂₃H₃₁ClFN₃O₅

[ 分子量 ]:
483.96

[ 外观性状 ]:
粉末

[ 储存条件 ]:
-20℃

一水西沙必利安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CU9372000

一水西沙必利文献

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Assay Drug Dev. Technol. 8 , 714-26, (2010)

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