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4-甲氧基-α－溴代苯乙酮

4-甲氧基-α－溴代苯乙酮用途

PTP inhibitor 1 是一种蛋白酪氨酸磷酸酶 (PTP) 抑制剂,具有抗血管生成活性。

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4-甲氧基-α－溴代苯乙酮名称

[ CAS 号 ]:
2632-13-5

[ 中文名 ]:
alpha-溴-4-甲氧基苯乙酮

[ 英文名 ]:
PTP inhibitor 1

[中文别名 ]:

[英文别名 ]:

α-Bromo-4'-methoxyacetophenone
p-methoxyphenacyl bromide
4'-Methoxyphenacyl Bromide
4-Methoxyphenacyl Br
ω-Bromo-4-methoxyacetophenone
2-Bromo-1-(4-methoxyphenyl)ethanone
4-Methoxyphenacyl bromide
2-Bromo-4′-methoxyacetophenone
2-Bromo-4‘-methoxyacetophenone
Acetophenone, 2-bromo-4'-methoxy-

4-甲氧基-α－溴代苯乙酮生物活性

[ 描述 ]:

PTP inhibitor 1 是一种蛋白酪氨酸磷酸酶 (PTP) 抑制剂,具有抗血管生成活性。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

[ 靶点 ]

PTP[1]

[体外研究]

PTP抑制剂1对HUVECs具有抗血管生成活性,IC50为3.7μM[1]。

[参考文献]

[1]. Sylvest L, et al. Phosphatase inhibitors with anti-angiogenic effect in vitro. APMIS. 2010 Jan;118(1):49-59.

4-甲氧基-α－溴代苯乙酮物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
306.7±17.0 °C at 760 mmHg

[ 熔点 ]:
69-71 °C(lit.)

[ 分子式 ]:
C₉H₉BrO₂

[ 分子量 ]:
229.071

[ 闪点 ]:
139.3±20.9 °C

[ 精确质量 ]:
227.978592

[ PSA ]:
26.30000

[ LogP ]:
2.27

[ 外观性状 ]:
淡棕色粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.554

[ 储存条件 ]:
2-8°C

4-甲氧基-α－溴代苯乙酮MSDS

4-甲氧基-α－溴代苯乙酮安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S27-S28-S36/37/39-S45-S37/39

[ 危险品运输编码 ]:
UN 3261 8/PG 2

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29147090

4-甲氧基-α－溴代苯乙酮合成路线

4-甲氧基-α－溴代苯乙酮上下游产品

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4-甲氧基-α－溴代苯乙酮海关

[ 海关编码 ]: 2914700090

[ 中文概述 ]:
2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

4-甲氧基-α－溴代苯乙酮文献

Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.

J. Med. Chem. 54 , 4042-56, (2011)

Development of kinase-targeted therapies for central nervous system (CNS) diseases is a great challenge. Glycogen synthase kinase 3 (GSK-3) offers a great potential for severe CNS unmet diseases, bein...

QSAR study and conformational analysis of 4-arylthiazolylhydrazones derived from 1-indanones with anti-Trypanosoma cruzi activity.

Eur. J. Pharm. Sci. 78 , 190-7, (2015)

A set of 4-arylthiazolylhydrazones derived from 1-indanones (TZHs) previously synthesized and assayed against Trypanosoma cruzi, the causative agent of Chagas disease, were explored in terms of confor...

Synthesis of diblock copolymers bearing p-methoxyphenacyl side groups.

Polym. Chem. 2(10) , 2284-2292, (2011)

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