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煙麴黴酸

煙麴黴酸用途

Helvolic acid (Fumigacin) 是从真菌中得到的抗生素,有效作用于革兰氏阳性菌。

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煙麴黴酸名称

[ CAS 号 ]:
29400-42-8

[ 中文名 ]:
煙麴黴酸

[ 英文名 ]:
Helvolic acid

[英文别名 ]:

hervolic acid
helvol acid
Helvolsaeure
Helvolic acid
Fumigacin

煙麴黴酸生物活性

[ 描述 ]:

Helvolic acid (Fumigacin) 是从真菌中得到的抗生素,有效作用于革兰氏阳性菌。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Ratnaweera PB, et al. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka. Mycology. 2014 Mar;5(1):23-28. Epub 2014 Mar 25.

煙麴黴酸物理化学性质

[ 密度 ]:
1.2g/cm3

[ 沸点 ]:
675.9ºC at 760 mmHg

[ 分子式 ]:
C₃₃H₄₄O₈

[ 分子量 ]:
568.69800

[ 闪点 ]:
209ºC

[ 精确质量 ]:
568.30400

[ PSA ]:
124.04000

[ LogP ]:
5.40010

[ 蒸汽压 ]:
5.01E-20mmHg at 25°C

[ 折射率 ]:
1.556

煙麴黴酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC1370000

CHEMICAL NAME :: 29-Nordammara-1,17(20),24-trien-21-oic acid, 6,16-bis(acetyloxy)-3,7-dioxo-, (4-alpha, 6-beta,8-alpha,9-beta,13-alpha,14-beta,16-beta,17-bet a)-

CAS REGISTRY NUMBER :: 29400-42-8

BEILSTEIN REFERENCE NO. :: 3230584

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C33-H44-O8

MOLECULAR WEIGHT :: 568.77

WISWESSER LINE NOTATION :: L E5 B666 FY LV OV PUTJ A1 FUYVQ3UY1&1 GOV1 I1 J1 KOV1 N1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,1837,1978