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曲酸

曲酸用途

Kojic acid 是由 Aspergillus oryzae 产生的物质,可也用作抗氧化剂和防辐射剂。
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曲酸名称

[ CAS 号 ]:
501-30-4

[ 中文名 ]:
曲酸

[ 英文名 ]:
kojic acid

[中文别名 ]:

[英文别名 ]:

曲酸生物活性

[ 描述 ]:

Kojic acid 是由 Aspergillus oryzae 产生的物质,可也用作抗氧化剂和防辐射剂。

[ 相关类别 ]:

研究领域 >> 感染
信号通路 >> 其他 >> 其他

[参考文献]

[1]. Wei X, et al. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2018 Dec 28;180:174-183.

曲酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
401.7±45.0 °C at 760 mmHg

[ 熔点 ]:
152-155 °C(lit.)

[ 分子式 ]:
C6H6O4

[ 分子量 ]:
142.11

[ 闪点 ]:
179.9±22.2 °C

[ 精确质量 ]:
142.026611

[ PSA ]:
70.67000

[ LogP ]:
-0.64

[ 外观性状 ]:
黄褐色粉末

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.607

[ 储存条件 ]:
Refrigerator

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
SOLUBLE

曲酸MSDS

详细MSDS(安全技术说明书)

曲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ0875000
CHEMICAL NAME :
4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
CAS REGISTRY NUMBER :
501-30-4
BEILSTEIN REFERENCE NO. :
0120895
LAST UPDATED :
199612
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C6-H6-O4
MOLECULAR WEIGHT :
142.12
WISWESSER LINE NOTATION :
T6O DVJ B1Q EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
4500 mg/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 59,213,1991
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曲酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UQ0875000

[ 海关编码 ]:
29329995

曲酸合成路线

详细合成路线

曲酸上下游产品

曲酸上游产品

曲酸下游产品

曲酸制备

1.工业上常用淀粉或糖蜜为原料进行发酵、精制而得。能生产曲酸的微生物是曲霉属（包括米曲霉、黄曲霉、白色曲霉、鱼坚曲霉、灰绿曲霉、亮白曲霉等）。

2.斜面菌种种子培养发酵罐培养↓培养基抽滤

3.滤液减压浓缩→结晶重结晶干燥曲酸成品.

4.是由多种曲霉素菌类和米曲霉代谢所产生的物质。
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曲酸海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

曲酸文献

Ciprofloxacin containing Mannich base and its copper complex induce antitumor activity via different mechanism of action.

Int. J. Oncol. 45(5) , 2092-100, (2014)

The Mannich base containing ciprofloxacin and kojic acid structural units was prepared and evaluated in antitumor activity. The enhancement in antitumor activity was observed both from the Mannich bas...

Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles.

Drug Des. Devel. Ther. 9 , 4259-68, (2015)

Tyrosinase is the most prominent target for inhibitors of hyperpigmentation because it plays a critical role in melaninogenesis. Although many tyrosinase inhibitors have been identified, from both nat...

Chemical compositions and biological activities of the essential oils of Beilschmiedia madang Blume (Lauraceae).

Arch. Pharm. Res. 38(4) , 485-93, (2015)

The present study aimed to examine the chemical compositions of the essential oils of Beilschmiedia madang and their antioxidant, antibacterial, antifungal, anticholinesterase and anti-tyrosinase acti...


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产品详情：Kojic acid

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相关化合物

【曲酸】化源网提供曲酸CAS号501-30-4，曲酸MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询曲酸上化源网，专业又轻松。>>电脑版：曲酸

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