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4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮

4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮用途

Ro 20-1724(Ro 20-174)是cAMP特异性磷酸二酯酶(PDE4/PDE IV)的有效抑制剂,Ki为1930nm。神经保护作用[1][2]。

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4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮名称

[ CAS 号 ]:
29925-17-5

[ 中文名 ]:
4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮

[ 英文名 ]:
RO 20-1724

[英文别名 ]:

MFCD00077397

4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮生物活性

[ 描述 ]:

Ro 20-1724(Ro 20-174)是cAMP特异性磷酸二酯酶(PDE4/PDE IV)的有效抑制剂,Ki为1930nm。神经保护作用[1][2]。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 神经疾病

[ 靶点 ]

PDE4:1930 nM (Ki)

[体内研究]

Ro 20-1724(125250和500μg/kg；静脉注射；首次静脉注射链脲佐菌素后21天；200-250 g成年(3-5个月大)雄性白化Wistar大鼠)显著减轻链脲佐菌素诱导的认知缺陷和氧化应激[2]。

[参考文献]

[1]. Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38(24):4848-4854.

[2]. Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101(2):239-245.

4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮物理化学性质

[ 密度 ]:
1.099 g/cm3

[ 沸点 ]:
483.8ºC at 760 mmHg

[ 分子式 ]:
C₁₅H₂₂N₂O₃

[ 分子量 ]:
278.35

[ 闪点 ]:
246.4ºC

[ 精确质量 ]:
278.16300

[ PSA ]:
59.59000

[ LogP ]:
2.75560

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
1.62E-09mmHg at 25°C

[ 折射率 ]:
1.521

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
ethanol: 7 mg/mL

4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮MSDS

详细MSDS(安全技术说明书)

4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮文献

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