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(S)-(+)-咯利普兰

(S)-(+)-咯利普兰用途

(S)-(+)-Rolipram是cAMP特异的PDE4抑制剂，有抗炎活性，活性小于其R型对映体。

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(S)-(+)-咯利普兰名称

[ CAS 号 ]:
85416-73-5

[ 中文名 ]:
(S)-4-[3-(环戊基氧基)-4-甲氧基苯基]-2-吡咯烷酮

[ 英文名 ]:
S-(+)-Rolipram

[中文别名 ]:

[英文别名 ]:

S2127_Selleck
1oyn
S- (+)-Rolipram
S-(+)-Rolipram
(-)-rolipram
1xn0
(+)-rolipram
(S)-(+)-Rolipram

(S)-(+)-咯利普兰生物活性

[ 描述 ]:

(S)-(+)-Rolipram是cAMP特异的PDE4抑制剂,有抗炎活性,活性小于其R型对映体。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)

研究领域 >> 炎症/免疫

[参考文献]

[1]. Griswold, D.E., et al., Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation, 1993. 17(3): p. 333-44.

[2]. Zhu, J., E. Mix, and B. Winblad, The antidepressant and antiinflammatory effects of rolipram in the central nervous system. CNS Drug Rev, 2001. 7(4): p. 387-98.

[3]. MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr

[4]. Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.

[相关活性小分子]

(S)-(+)-咯利普兰物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
472.7±45.0 °C at 760 mmHg

[ 熔点 ]:
133-136ºC

[ 分子式 ]:
C₁₆H₂₁NO₃

[ 分子量 ]:
275.343

[ 闪点 ]:
239.7±28.7 °C

[ 精确质量 ]:
275.152130

[ PSA ]:
47.56000

[ LogP ]:
1.43

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
Store at RT

(S)-(+)-咯利普兰安全信息

[ 海关编码 ]:
2933790090

(S)-(+)-咯利普兰合成路线

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(S)-(+)-咯利普兰海关

[ 海关编码 ]: 2933790090

[ 中文概述 ]:
2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:9.0% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%